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金黃色葡萄球菌的致病及抗藥機制

 

Pathogenesis and drug resistance of Staphylococcus aureus

金黃色葡萄球菌的致病及抗藥機制

 

 

 

陳逢叡 Feng-Jui Chen

助研究員Assistant Investigator
Phone: 886-37-246166 ext.35518/35532
Fax: 886-37-586457
E-mail: frchen@nhri.org.tw


 

 

Dr. Chen received his Ph.D. degree from NationalTaiwanOceanUniversity in 1999 and became a Postdoctoral Fellow in NHRI thereafter. In 2003, he applied for an overseas postdoctoral fellowship training program in the Institute of Infection, Immunity and Inflammation, University of Nottingham, UK. In February 2006, he became an Assistant Investigator of Division of Clinical Research at NHRI and major in Staphylococcal pathogenesis and drug resistance.

 

Research Interests

 

 


Staphylococcus aureus is one of the most important human pathogens; especially methicillin-resistant S. aureus (MRSA) is an emerging global problem in both community and nosocomial infections. The most common clinical infections by S. aureus are skin and tissue infections, food poisoning, bacteremia, osteomyelitis and toxic shock syndrome. Virulence toxins are the major factors of staphylococcal infections. Most of these virulence toxins are controlled by the accessory gene regulator (agr) locus, which belongs to a quorum sensing system and is responsible for the cell density via autoinducing peptide (AIP) signal molecules. S. aureus strains have so far been divided into four agr groups based on their ability to cross-activate or inhibit agr expression. Intra-group activation and inter-group inhibition are both mediated by the same group-specific AgrC receptor. This kind of inhibition could refer as a type of bacterial interference that does not involved in growth inhibition, but rather is mediated by inhibition of the synthesis of virulence factors. This type of bacterial interference has been proven to be operative in blocking abscess formation in mouse infection model, providing a promising therapeutic alternative to control infections in the era of increasing antibiotic resistance.

In addition to the pathogenesis projects, our laboratory also studies the mechanisms of methicillin resistance in S. aureus.

 

Selected Publications

1.      McDonald, L. C., Chen, F. J., Lo, H. J., Yin, H. C., Lu, P. L., Huang, C. H., Chen, P., Lauderdale, T. L., & Ho, M. (2001). Emergence of reduced susceptibility and resistance to fluoroquinolones in Escherichia coli in Taiwan and contributions of distinct selective pressures. Antimicrob. Agents Chemother., 45, 3084-3091.

2.      Chen, F. J., McDonald, L. C., Ho, M., & Lo, H. J. (2001). Identification of reduced fluoroquinolone susceptibility in Escherichia coli: a herald for emerging resistance. J Antimicrob. Chemother., 48, 936-938.

3.      Chen, F. J., Lauderdale, T. L., Ho, M., & Lo, H. J. (2003). The roles of mutations in gyrA, parC, and ompK35 in fluoroquinolone resistance in Klebsiella pneumoniae. Microb. Drug Resist., 9, 265-271.

4.      Chen, F. J., Lauderdale, T. L., McDonald, L. C., Chen, P. C., Yin, H. C., Ho, M., & Lo, H. J. (2004). Molecular epidemiology of the emerging fluoroquinolone reduced-susceptible Escherichia coli. J Med. Microbiol., 53, 85-86.

5.      Chen, F. J., Lauderdale, T. L., Huang, I. W., Lo, H. J., Lai, J. F., Wang, H. Y., Shiau, Y. R., Chen, P. C., Ito, T., & Hiramatsu, K. (2005). Methicillin-resistant Staphylococcus aureus in Taiwan. Emerg Infect Dis., 11:1761-1763.

6.      Lu, P. L., Chang, J. C., Hsu, H. T., Chen, J. H., Chen, F. J., Lin, S. F., Siu, L. K. (2008). One tube multiplex PCR for simple screening of SCCmec I-V types of methicillin-resistant Staphylococcus aureus. J Chemother., 20:690-696.

 

 

 

 


 

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