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Dr. Huai-Chia Chuang

Dr. Huai-Chia Chuang  莊懷佳 助研究員                            Profile updated: Jan. 11, 2017
Assistant Investigator                                                                                         ResearcherID: E-9486-2016    
Immunology Research Center, National Health Research Institutes                   
[Contact Information]
Phone      +886-37-246166 Ext. 37616
Fax            +886-37-586642
Email        cinth@nhri.org.tw
Address  3F, Bldg R1, 35 Keyan Road, Zhunan, Miaoli County 350, Taiwan (R.O.C.)

 

SPECIALITY & RESEARCH FIELD OF INTEREST

    
Dr. Chuang is interested in studying the T-cell-mediated immune responses and inflammatory disease mechanisms. Dr. Chuang demonstrated that the kinase MAP4K3 (GLK) positively regulates T-cell activation and NF-κB signaling through phosphorylating and activating PKC-θ. Recently, Dr. Chuang’s study revealed a novel subset of Th17 cells, adipose Th17 cells, and discovered a novel disease mechanism of T-cell-mediated type 2 diabetes (T2D). Dr. Chuang’s current research focuses on studying the immunometabolism in T2D.

|     EDUCATION AND POSITIONS   |   HONORS   |   PUBLICATIONS |

 EDUCATIONS AND POSITIONS

1997 2001

B.S., Department of Botany, National Taiwan University, Taipei, Taiwan.

2001 2003

M.S., Graduate Institute of Pathology, National Taiwan University, Taipei, Taiwan.

2004 2008

Ph.D., Institute of Basic Medical Sciences, National Cheng-Kung University, Tainan, Taiwan.

2008 – 2014

Postdoctoral Fellow, Immunology Research Center, National Health Research Institutes, Taiwan.

2014 – 2015

Assistant Research Fellow (Assistant Professor equivalent), Research and Development Center for Immunology, China Medical University, Taiwan.

2015 – present

Assistant Investigator, Immunology Research Center, National Health Research Institutes, Taiwan.

 


HONORS

2010

14th International Congress of Immunology, Travel Award, Kobe, Japan

2012

10th YuZiang Hsu Scientific Paper Award for Bio-medical Technology (徐有庠科技論文獎).

2013

National Science Council (NSC) Best Research Paper Award for Postdoctoral Fellows (國科會第一屆博士後研究人員學術著作獎)

2013

15th International Congress of Immunology, Travel Award, Milano, Italy

2013

Federation of Immunological Societies of Asia-Oceania (FIMSA), Travel Award for 15th ICI

2016

Federation of Immunological Societies of Asia-Oceania (FIMSA), Travel Award for 16th ICI


 PUBLICATIONS

1.  Chuang HC, Lay JD, Hsieh WC, Wang HC, Chang Y, Chuang SE, Su IJ. (2005) Epstein-Barr virus LMP1 inhibits the expression of SAP gene and upregulates Th1 cytokines in the pathogenesis of hemophagocytic syndrome. Blood. 10:3090-3096.

2.   Hsieh WC, Chang Y, Hsu MC, Lan BS, Hsiao GC, Chuang HC, Su IJ. (2007) Emergence of anti-red blood cell antibodies triggers red cell phagocytosis by activated macrophages in a rabbit model of Epstein-Barr virus-associated hemophagocytic syndrome. American Journal of Pathology. 170:1629-1639.

3.   Chuang HC, Lay JD, Chuang SE, Hsieh WC, Chang Y, Su IJ. (2007) Epstein-Barr virus (EBV) latent membrane protein-1 down-regulates tumor necrosis factor-alpha (TNF-α) receptor-1 and confers resistance to TNF-α-induced apoptosis in T cells: implication for the progression to T-cell lymphoma in EBV-associated hemophagocytic syndrome. American Journal of Pathology. 170:1607-1617.

4.   Chuang HC, Lay JD, Hsieh WC, Su IJ. (2007) Pathogenesis and mechanism of disease progression from hemophagocytic lymphohistiocytosis to Epstein-Barr virus-associated T-cell lymphoma: nuclear factor-κB pathway as a potential therapeutic target. Cancer Science. 98:1281-1287.

5.   Chuang HC, Wang JM, Hsieh WC, Chang Y, Su IJ. (2008) Up-regulation of activating transcription factor-5 suppresses SAP expression to activate T cells in hemophagocytic syndrome associated with Epstein-Barr virus infection and immune disorders. American Journal of Pathology. 173:1397-1405.

6.   Yang JC, Teng CF, Wu HC, Tsai HW, Chuang HC, Tsai TF, Hsu YH, Huang W, Wu LW, Su IJ. (2009) Enhanced expression of vascular endothelial growth factor-A in ground glass hepatocytes and its implication in hepatitis B virus hepatocarcinogenesis. Hepatology. 49:1962-1971.

7.   Chuang HC, Lan JL, Chen DY, Yang CY, Chen YM, Li JP, Huang CY, Liu PE, Wang X, and Tan TH. (2011). The kinase GLK controls autoimmunity and NF-kB signaling by activating the kinase PKC-q in T cells. Nature Immunology. 12:1113-1118.

Highlighted in News & Views “PKC-θ: hitting the bull’s eye”, Nature Immunology. 12:1031-1032.

Highlighted in Science-Business eXchange (SciBX), 4:42 (Oct. 27, 2011)

Highlighted in A-IMBN Research (Dec. 27, 2011).

8.  Chen DY, Chuang HC, Lan JL, Chen YM, Hung WT, Lai KL, Tan TH. (2012) Germinal center kinase (GCK)-Like kinase (GLK/MAP4K3) expression is increased in adult-onset Still’s disease and may act as an activity marker. BMC Medicine. 10:84.

9.   Wang X, Chuang HC, Li JP, and Tan TH. (2012) Regulation of PKC-θ function by phosphorylation in T cell receptor signaling. Frontiers in Immunology. 3: 197.

10. Chen YM*, Chuang HC*, Lan JL, Hung WT, Lin YT, Gong NR, Lin WC, Lan TH, Tan TH, Chen DY. (2013) GLK overexpression in T cells as a novel biomarker of rheumatoid arthritis. Arthritis & Rheumatism. 65: 2573-2582. *, co-first author with equal contribution.

11.  Yang CY, Li JP, Lan JL, Chiu LL, Chuang HC, Huang CY, Chen DY, Tan TH. (2014) Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates T-cell receptor signaling by inhibiting TAK1 activation. Journal of Immunology. 192:1547-1557.

12. Li JP, Yang CY, Chuang HC, Huang PY, Chen YR, Wang X, Belmont J, and Tan TH. (2014) The phosphatase JKAP/DUSP22 inhibits T-cell receptor signaling and autoimmunity by inactivating Lck. Nature Communications. 5:3618.

13. Chuang HC, Sheu W, Lin YT, Tsai CY, Yang CY, Cheng YJ, Huang PY, Li JP, Chiu LL, Wang X, Xie M, Schneider M, and Tan TH. (2014) HGK/​MAP4K4 deficiency induces TRAF2 stabilization and Th17 differentiation leading to insulin resistance. Nature Communications. 5: 4602.

14. Chuang HC, Wang X, Tan T.-H. 2016. MAP4K family kinases in immunity and inflammation. Advances in Immunology. 129:277-314.

15. Chuang HC, JS Wang, IT Lee, W H-H. Sheu* and Tan, T.-H*. 2016. Epigenetic regulation of HGK/MAP4K4 in T cells of type 2 diabetes patients. Oncotarget. 7:10976-10989.

16. Hsu CP, Chuang HC, Lee MC, Tsou HH, Lee LW, Li JP, Tan, T.-H*. 2016. GLK/MAP4K3 overexpression associates with recurrence risk for non-small cell lung cancer. Oncotarget. 7:41748-41757.

17. Ho CH, Chuang HC, Wu IC, Tsai HW, Lin YJ, Sun HY, Young KC, Chiu YC, Cheng PN, Liu WC, Tan, T.-H* and Chang TT* 2016. Prediction of early hepatocellular carcinoma recurrence using germinal center kinase-like kinase. Oncotarget. 7:49765-49776.

18. Chuang HC, YM Chen, WT. Hung, JP. Li, DY. Chen*, JL. Lan* and Tan, T.-H*. 2016. Downregulation of the phosphatase JKAP/DUSP22 in T Cells as a potential new biomarker of systemic lupus erythematosus nephritis. Oncotarget. 7:57593-57605.

19. Chuang, HC and T.-H. Tan*. 2017. MAP4K4 and IL-6+ Th17 cells play important roles in non-obese type 2 diabetes. Journal of Biomedical Science. (Invited review) 2017. 24:4.

 


 

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