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Shu-Chen Kuo

郭書辰 副研究員級主治醫師
感染症與疫苗研究所
連絡電話:037-246166 # 35527
E-mail:sckuo@nhri.org.tw

學歷


2010/09 - 2015/06     PhD, Institute of Clinical Medicine, National Yang-Ming University, Taipei
1998/09 - 2005/06     M.D., College of Medicine, National Taiwan University, Taipei

經歷

2014/10 - present     Assistant investigator and attending physician, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes
2011/08 - 2014/10     Attending physician, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes
2008/12 - 2010/12     Chief Resident, Division of Infectious Diseases, Taipei Veterans General Hospital, Taipei
2005/07 - 2008/07     Resident, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei

行政兼職

 



Research Interests

Dr. Kuo is a graduate of National Taiwan University (NTU) and performed his internship in the NTU hospital. Dr. Kuo performed internal medicine and infectious disease specialty training in Taipei Veterans General Hospital. He is the attending physician and assistant investigator at National Health Research Institutes. His research interest is mainly on clinical microbiology of resistant pathogens, especially Acinetobacter spp. He is also the author of many population-based papers on antibiotic use and infectious diseases.



Research Activities & Accomplishment

 



Publications

Publications:

1.           Chiang MH, Wu HH, Shih CJ, Chen YT, Kuo SC, Chen TL (2017, Nov). Association between influenza vaccination and reduced risks of major adverse cardiovascular events in elderly patients.. Am Heart J, 2017 Nov;193:1-7. 本人為通訊作者.
2.           Lee YT, Wang YC, Kuo SC, Chen CT, Liu CP, Liu YM, Chen TL, Yang YS. (2017, Aug). Multicenter Study of Clinical Features of Breakthrough Acinetobacter Bacteremia during Carbapenem Therapy.. Antimicrobial Agents and Chemotherapy, 24;61(9)..
3.           Yang YS, Wang YC, Kuo SC, Chen CT, Liu CP, Liu YM, Chen TL, Lee YT. (2017, Aug). Multicenter Study of the Relationship between Carbapenem MIC Values and Clinical Outcome of Patients with Acinetobacter Bacteremia.. Antimicrobial Agents and Chemotherapy, 24;61(9).
4.           Yang FL, Lou TC, Kuo SC, Wu WL, Chern J, Lee YT, Chen ST, Zou W, Lin NT, Wu SH (2017, May). A medically relevant capsular polysaccharide in Acinetobacter baumannii is a potential vaccine candidate.. Vaccine, 7;35(10):1440-1447.
5.           Kuo SC, Shih SM, Hsieh LY, Lauderdale TY, Chen YC, Hsiung CA, Chang SC (2017, Feb). Antibiotic restriction policy paradoxically increased private drug consumptions outside Taiwan's National Health Insurance. Journal of Antimicrobial Chemotherapy , [Epub ahead of print] . 本人為第一作者.
6.           Chen YY, Huang WT, Chen CP, Sun SM, Kuo FM, Chan YJ, Kuo SC, Wang FD (2017, Jan). An Outbreak of Ralstonia pickettii Bloodstream Infection Associated with an Intrinsically Contaminated Normal Saline Solution.. Infection Control & Hospital Epidemiology, [Epub ahead of print].
7.           Chang YY, Liu YM, Liu CP, Kuo SC, Chen TL; ACTION study group (2017). Impact of reduced tigecycline susceptibility on clinical outcomes of Acinetobacter bacteremia. . J Microbiol Immunol Infect., [Epub ahead of print]. 本人為通訊作者.
8.           Chiu CH, Liu YH, Wang YC, Lee YT, Kuo SC, Chen TL, Lin JC1, Wang FD. (2016, Dec). In vitro activity of SecA inhibitors in combination with carbapenems against carbapenem-hydrolysing class D β-lactamase-producing Acinetobacter baumannii. Journal of Antimicrobial Chemotherapy, 71(12):3441-3448.
9.           Lee YT, Chiang MC, Kuo SC, Wang YC, Lee IH, Chen TL, Yang YS (2016, Sep). Carbapenem Breakpoints for Acinetobacter baumannii Group: Supporting Clinical Outcome Data from Patients with Bacteremia. PLoS One, 11(9):e0163271.
10.        Kuo SC, Huang WC, Wang HY, Shiau YR, Cheng MF, Lauderdale TL (2016, Aug). Colistin resistance gene mcr-1 in Escherichia coli isolates from humans and retail meats, Taiwan. Journal of Antimicrobial Chemotherapy, 71(8):2327-9. 本人為第一作者.
11.        Ou SM, Chu H, Chao PW, Lee YJ, Kuo SC, Chen TJ, Tseng CM, Shih CJ, Chen YT (2016, Jul). Long-term Mortality and Major Adverse Cardiovascular Events in Sepsis Survivors: A Nationwide Population-based Study.. American Journal of Respiratory and Critical Care Medicine, 194(2):209-17.
12.        Wang YC, Kuo SC, Yang YS, Lee YT, Chiu CH, Chuang MF, Lin JC, Chang FY, Chen TL. (2016, Jul). Individual or combined effects of meropenem, imipenem, sulbactam, colistin, and tigecycline on biofilm-embedded Acinetobacter baumannii and biofilm architecture.. Antimicrobial Agents and Chemotherapy , 60(8):4670-6.
13.        Chao PW, Chu H, Chen YT, Shih YN, Kuo SC, Li SY, Ou SM, Shih CJ (2016, Jun). Long-Term Outcomes in Critically Ill Septic Patients Who Survived Cardiopulmonary Resuscitation.. Critical Care Medicine, 44(6):1067-74.
14.        Yang YS, Lee Y, Tseng KC, Huang WC, Chuang MF, Kuo SC, Lauderdale TL, Chen TL (2016, Jun). In Vivo and In Vitro Efficacy of Minocycline-Based Combination Therapy for Minocycline-Resistant Acinetobacter baumannii.. Antimicrobial Agents and Chemotherapy, 60(7):4047-54. MOST 103-2314-B-400-020-MY2. 本人為通訊作者.
15.        Shih CJ, Ou SM, Chao PW, Kuo SC, Lee YJ, Yang CY, Tarng DC, Lin CC, Huang PH, Li SY, Chen YT (2016, Jan). Risks of Death and Stroke in Patients Undergoing Hemodialysis With New-Onset Atrial Fibrillation: A Competing-Risk Analysis of a Nationwide Cohort.. Circulation, 133(3):265-72.
16.        Liao YT, Kuo SC, Chiang MH, Lee YT, Sung WC, Chen YH, Chen TL, Fung CP. (2015, Dec). Acinetobacter baumannii extracellular OXA-58 is primarily and selectively released via outer membrane vesicles after Sec-dependent periplasmic translocation.. Antimicrobial Agents and Chemotherapy , 59(12):7346-54.
17.        Huang TW, Lauderdale TL, Liao TL, Hsu MC,Chang FY, Chang SC, Khong WX, Ng OT, Chen YT, Kuo SC, Chen TL, Mu JJ, Tsai SF. (2015, Oct). Effective transfer of a 47 kb NDM-1-positive plasmid among Acinetobacter species. . Journal of Antimicrobial Chemotherapy. , 70(10):2734-8.
18.        Kuo SC, Lee YT, Yang Lauderdale TL, Huang WC, Chuang MF, Chen CP, Su SC, Lee KR, Chen TL. (2015, May). Contribution of Acinetobacter-derived cephalosporinase-30 to sulbactam resistance in Acinetobacter baumannii.. Frontiers in Microbiology., 6:231. 本人為第一作者.
19.        Liou BH, Lee YT, Kuo SC, Liu PY, Fung CP. (2015, Mar). Efficacy of tigecycline for secondary Acinetobacter bacteremia and factors associated with treatment failure. . Antimicrobial Agents and Chemotherapy , 59(6):3637-40. 本人為通訊作者.
20.        Hau-Hsin Wu,Yung-Tai Chen,Chia-Jen Shih,Yi-Tzu Lee,Shu-Chen Kuo,Te-Li Chen (2014, Dec). Association Between Recent Use of Proton Pump Inhibitors and Nontyphoid Salmonellosis: A Nested Case-Control Study. Clinical Infectious Diseases , 59(11):1554-8. 本人為通訊作者.
21.        Chao PW, Shih CJ, Lee YJ, Tseng CM, Kuo SC, Shih YN, Chou KT, Tarng DC, Li SY, Ou SM, Chen YT (2014, Nov). Association of postdischarge rehabilitation with mortality in intensive care unit survivors of sepsis.. American Journal of Respiratory and Critical Care Medicine, 190(9):1003-11.
22.        Chia-Jen Shih,Hsi Chu,Pei-Wen Chao,Yi-Jung Lee,Shu-Chen Kuo, Szu-Yuan Li,Der-Cherng Tarng,Chih-Yu Yang,Wu-Chang Yang,Shuo-Ming Ou,Yung-Tai Chen (2014, Nov). Long-Term Clinical Outcome of Major Adverse Cardiac Events in Survivors of Infective Endocarditis. circulation, 130(19):1684-91.
23.        Shu-Chen Kuo, Pei-Chen Chen, Yih-Ru Shiau, Hui-Ying Wang, Jui-Fen Lai, Wen Huang, and Tsai-Ling Yang (2014, Aug). Levofloxacin-resistant haemophilus influenzae, Taiwan, 2004-2010.. Emerging Infectious Diseases, 20(8):1386-90. 本人為第一作者.
24.        Yu-Ting Liaoa, Shu-Chen Kuoa,b, Yi-Tzu Leea,c, Chien-Pei Chend, Shu-Wen Line, Li-Jiuan Shene, Chang-Phone Fungd,f, Wen-Long Choa,g and Te-Li Chena (2014, Jul). Sheltering Effect and Indirect Pathogenesis of Carbapenem-Resistant Acinetobacter baumannii in Polymicrobial Infection. Antimicrobial Agents and Chemotherapy , 58(7):3983-90.
25.        Kuo SC, Chen YT, Lee YT, Fan NW, Chen SJ, Li SY, Liu CJ, Chen TL, Chen TJ, Fung CP. (2014, Jan). Association between recent use of fluoroquinolones and rhegmatogenous retinal detachment: a population-based cohort study.. Clinical Infectious Diseases, 58(2):197-203. 本人為第一作者.
26.        Kuo SC, Lee YT, Yang SP, Chiang MC, Lin YT, Tseng FC, Chen TL, Fung CP. (2013, Jul). Evaluation of the effect of appropriate antimicrobial therapy on mortality associated with Acinetobacter nosocomialis bacteraemia.. Clinical Microbiology and Infection, 19(7):634-9. 本人為第一作者.
27.        Kuo SC, Chang SC, Wang HY, Lai JF, Chen PC, Shiau YR, Huang IW, Lauderdale TL; TSAR Hospitals. (2012, Aug). Emergence of extensively drug-resistant Acinetobacter baumannii complex over 10years: Nationwide data from the Taiwan Surveillance of Antimicrobial Resistance (TSAR) program.. BMC Infectious Diseases, 12:200. 本人為第一作者.
28.        Lee YT, Kuo SC, Yang SP, Lin YT, Tseng FC, Chen TL, Fung CP. (2012, Jul). Impact of appropriate antimicrobial therapy on mortality associated with Acinetobacter baumannii bacteremia: relation to severity of infection.. Clinical Infectious Diseases, 55(2):209-15.
29.        Lee YT, Kuo SC, Chiang MC, Yang SP, Chen CP, Chen TL, Fung CP. (2012, Feb). Emergence of carbapenem-resistant non-baumannii species of Acinetobacter harboring a blaOXA-51-like gene that is intrinsic to A. baumannii.. Antimicrobial Agents and Chemotherapy, 56(2):1124-7.
30.        Kuo SC, Chiang MC, Lee WS, Chen LY, Wu HS, Yu KW, Fung CP, Wang FD. (2012, Jan). Comparison of microbiological and clinical characteristics based on SCCmec typing in patients with community-onset meticillin-resistant Staphylococcus aureus (MRSA) bacteraemia.. International Journal of Antimicrobial Agents, 39(1):22-6. 本人為第一作者.
31.        郭書辰 楊采菱(201702月)。新型抗藥基因 mcr-1 (Plasmid-Mediated Colistin Resistance)感染控制雜誌,第二十七卷一期。本人為第一作者。
32.        郭書辰, 石舒嫚, 楊采菱, 陳宜君, 熊昭, 張峰義, 莊銀清, 陳垚生, 馮長風, 張上淳(201502月)。Fluoroquinolone抗藥性台灣社區現況。感控雜誌26(1), 31-37。本人為第一作者。


Lab Member

姓 名 職 稱 分機 E-mail
黃偉晟 研究助理 35542 ls0410@nhri.org.tw
曾國權 研究助理 35542 tkcsnhri@nhri.org.tw
羅亦茹 研究助理 35542

更新日期:2017-11-28

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