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Chia-Yi Yu

余佳益 助研究員
感染症與疫苗研究所
連絡電話：06-7000-123#65261
E-mail：epitope@nhri.org.tw

經歷
2017/08 - present     Assistant Investigator, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Tainan, Taiwan
2017/08 - present     Adjunct Assistant Professor, Department of Microbiology and Immunology, National Cheng Kung University, Tainan, Taiwan
2016/08 - 2017/07     Project Assistant Professor, Department of Microbiology and Immunology, National Cheng Kung University, Tainan, Taiwan
2014/08 - 2016/07     Project Assistant Professor, Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University, Tainan, Taiwan
2014/01 - 2014/07     Postdoctoral Fellow, Virology, Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan
2007/02 - 2013/12     Postdoctoral Research Fellowship, Virology, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
1998/08 - 1999/01     Intern, Medical Technician, Taipei Mackay Memorial Hospital, Taipei, Taiwan
1997/07 - 1997/08     Summer Student, Functional Magnetic Resonance Imaging, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan

Honors & Awards

2013 Postdoctoral Fellow Outstanding Publication Awards, National Science Council of Taiwan
2012 2012 Research Competition Award for Attending International Conference (Ph.D. group), Institute of Biomedical Sciences, Academia Sinica
2012 10th Joint Meeting of the ICS/ISICR in Geneva, Travel Award
2009 2009 Research Competition Award for Attending International Conference (Ph.D. group), Institute of Biomedical Sciences, Academia Sinica
2008 - 2009 The Academia Sinica Postdoctoral Fellowship Award
2005 2nd Asian Regional Dengue Research Network Meeting, Travel Award
2004 2004 Research Competition Award for Attending International Conference (student group), Institute of Biomedical Sciences, Academia Sinica
2000 The scholarship winner of the Zong-Ren Chen Immunology Research and Development Foundation (as the top graduate student)
1998 The winner of the annual student in medical technicians in Taipei Mackay Memorial Hospital (as the top intern student)

行政兼職

 

Research Interests

 

RESEARCH TOPICS

1.          Investigation of the virus-host interactions in flavivirus infection

2.          Suppression/induction of innate immunity by dengue virus

3.          Regulatory factors involved in the cGAS/STING mediated innate immunity

 

The focus of my research is on the interaction between viruses and their hosts in molecular level. The most recognized work of mine until now was the identification of a key molecule in response to virus infection, MITA/STING, as the host substrate of dengue viral protease. Cleavage of this protein dramatically impairs interferon pathway and benefits dengue virus replication. Currently, I am studying the biological functions of host and viral proteins involved in innate immunity, metabolism, and mitochondrial biology.

 

Publications

1.     Yi-Lin Cheng, Yee-Shin Lin, Chia-Ling Chen, Tsung-Ting Tsai, Cheng-Chieh Tsai, Yan-Wei Wu, Yi-Dan Ou, Yu-Yi Chu, Ju-Ming Wang, Chia-Yi Yu & Chiou-Feng Lin. Activation of Nrf2 by the dengue virus causes an increase in CLEC5A, which enhances TNF-α production by mononuclear phagocytes. Scientific Reports 2016 Aug 26;6:32000.

2.     Yan-Wei Wu, Clément Mettling, Shang-Rung Wu, Chia-Yi Yu, Guey-Chuen Perng, Yee-Shin Lin & Yea-Lih Lin. Autophagy-associated dengue vesicles promote viral transmission avoiding antibody neutralization. Scientific Reports 2016 Aug 25;6:32243.

3.     Chan-I Su, Chung-Hsin Tseng, Chia-Yi Yu and Michael M. C. Lai. SUMO Modification Stabilizes Dengue Virus Nonstructural Protein 5 to Support Virus Replication. Journal of Virology (2016) Apr 90(9): 4308-19. (co-corresponding author)

4.     Chia-Yi Yu, Jian-Jong Liang, Jin-Kun Li, Yi-Ling Lee, Bi-Lan Chang, Chan-I Su, Wei-Jheng Huang, Michael M. C. Lai and Yi-Ling Lin. Dengue Virus Impairs Mitochondrial Fusion by Cleaving Mitofusins. PLoS Pathogens (2015) Dec 11(12): e1005350. (co-corresponding author)

5.     Yi-Lin Cheng, Yee-Shin Lin, Chia-Ling Chen, Shu-Wen Wan, Yi-Dan Ou, Chia-Yi Yu, Chiou-Feng Lin, Tsung-Ting Tsai and Po-Chun Tseng. Dengue virus infection causes the activation of distinct NF-kB pathways for inducible nitric oxide synthase and TNF-a expression in RAW264.7 cells. Mediators of Inflammation (2015) Jun 2015: 274025.

6.     Li-Fong Wang, You-Sheng Lin, Nan-Chieh Huang, Chia-Yi Yu, Wei-Lun Tsai, Jih-Jung Chen, Toru Kubota, Mayumi Matsuoka, Siang-Ru Chen, Chih-Shiang Yang, Ruo-Wei Lu, Yi-Ling Lin, and Tsung-Hsien Chang. Hydroxychloroquine-Inhibited Dengue Virus Is Associated with Host Defense Machinery. J Interferon Cytokine Res. (2015) Mar 35(3):143-56

7.     Hom-Ming Yeh, Chia-Yi Yu, Ho-Chun Yang, Shih-Han Ko, Ching-Len Liao, and Yi-Ling Lin. Ubiquitin-specific protease 13 regulates interferon signaling by stabilizing STAT1. Journal of Immunology (2013) Sep 191(6):3328-36.

8.     Yu-Chun Tu, Chia-Yi Yu, Jian-Jong Liang, Elong Lin, Ching-Len Liao, and Yi-Ling Lin. Blocking dsRNA-Activated Protein Kinase PKR by Japanese Encephalitis Virus Nonstructural Protein 2A. Journal of Virology (2012) Oct 86(19):10347-58.

9.     Tsung-Hsien Chang, Siang-Ru Chen, Chia-Yi Yu, You-Sheng Lin, Yao-Shen Chen, Toru Kubota, Mayumi Matsuoka and Yi-Ling Lin. Dengue virus serotype 2 blocks extracellular signal-regulated kinase and nuclear factor-kB activation to downregulate cytokine production. PLoS One (2012) Aug 7(8): e41635.

10. Chia-Yi Yu, Tsung-Hsien Chang, Jian-Jong Liang, Ruei-Lin Chiang, Yi-Ling Lee, Ching-Len Liao and Yi-Ling Lin. Dengue virus targets the adaptor protein MITA to subvert host innate immunity. PLoS Pathogens (2012) Jun 8(6): e1002780. [國科會博士後研究人員學術著作獎]

11. Jian-Jong Liang, Chia-Yi Yu, Ching-Len Liao, and Yi-Ling Lin. Vimentin binding is critical for infection by the virulent strain of Japanese encephalitis virus. Cellular Microbiology (2011) Sep 13(9):1358-70.

12. Chia-Yi Yu, Ruei-Lin Chiang, Tsung-Hsien Chang, Ching-Len Liao, and Yi-Ling Lin. The interferon stimulator mitochondrial antiviral signaling protein facilitates cell death by disrupting the mitochondrial membrane potential and by activating caspases. Journal of Virology (2010) Mar 84(5):2421-31.

13. Chia-Yi Yu, Yun-Wei Hsu, Ching-Len Liao, and Yi-Ling Lin. Flavivirus infection activates the XBP1 pathway of the unfolded protein response to cope with endoplasmic reticulum stress. Journal of Virology (2006) Dec 80(23):11868-80.

Lab Member
姓 名 職　稱 分機 E-mail
高毓婷 博士後研究員 65270
汪欣儀 研究助理 65218
謝其庭 研究助理 65215
蘇展儀 研究助理 65215
莊子萱 研究助理 65218
林建皓 碩士班研究生 65218

更新日期：2019-06-03

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