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Yao Chang

張堯 副研究員
感染症與疫苗研究所
連絡電話:06-2083422 ext. 65261
傳真電話:06-2083466
E-mail:yaochang@nhri.org.tw

學歷


1994/09 - 2000/06     Ph.D., Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
1991/09 - 1994/06     B.Sc., Department of Zoology, Zoology Division, College of Science, National Taiwan University, Taipei, Taiwan

經歷

2012/08 - present     Adjunct Associate Professor, Department of Microbiology and Immunology, National Cheng Kung University, Tainan, Taiwan
2011/04 - present     Associate Investigator, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Tainan, Taiwan
2009/09 - present     Adjunct Assistant Professor, Graduate Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan
2009/02 - 2012/07     Adjunct Assistant Professor, Department of Microbiology and Immunology, National Cheng Kung University, Tainan, Taiwan
2005/01 - 2011/03     Assistant Investigator, Division of Clinical Research/Infectious Diseases, National Health Research Institutes, Tainan, Taiwan
2000/11 - 2004/12     Postdoctoral fellow, Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan

Honors & Awards


2012 Research Achievement Award for Junior Research Investigators, National Health Research Institutes
2001 Outstanding Publication Award for Graduate Students of College of Medicine, National Taiwan University
2001 Postdoctoral Fellowship Award, National Health Research Institutes
2000 Honorary Member of the Phi Tau Phi Scholastic Honor Society at National Taiwan University
1995 Professor Chih-Chung Yen’s Scholarship Award of Chinese Society of Microbiology
1994 Presidential Award of Undergraduate Students at National Taiwan University
1993 Presidential Award of Undergraduate Students at National Taiwan University
1992 Presidential Award of Undergraduate Students at National Taiwan University

行政兼職

 



Research Interests

 

Regulation and cellular effects of Epstein-Barr virus infection and reactivation

Roles of cellular stress in Epstein-Barr virus-associated cancers

Immuno-regulation in the microenvironment of Epstein-Barr virus-associated cancers



Research Activities & Accomplishment

 



Publications

 Publications: (*corresponding author; #co-first author)

1.          Chung-Chun Wu, Shin-Ying Chuang, Chao-Yi Lin, Yen-Ju Chen, Wan-Hua Tsai, Chih-Yeu Fang, Sheng-Yen Huang, Fu-Yang Chuang, Su-Fang Lin, Yao Chang, and Jen-Yang Chen (2012). Inhibition of Epstein-Barr virus reactivation in nasopharyngeal carcinoma cells by dietary sulforaphane. Molecular Carcinogenesis, in press. doi:10.1002/mc.21926.

2.          Chih-Yeu Fang, Sheng-Yen Huang, Chung-Chun Wu, Hui-Yu Hsu, Sheng-Ping Chou, Ching-Hwa Tsai, Yao Chang, Kenzo Takada, and Jen-Yang Chen (Sep. 2012). The synergistic effect of chemical carcinogens enhances Epstein-Barr virus reactivation and tumor progression of nasopharyngeal carcinoma cells. PLoS ONE, 7(9):e44810. doi:10.1371/journal.pone.0044810.

3.          Yu-Yan Lan, Jenn-Ren Hsiao, Kung-Chao Chang, Jeffrey Shu-Ming Chang, Chaio-Wei Chen, Hsiao-Ching Lai, Shih-Yi Wu, Tzu-Hao Yeh, Fang-Hsin Chang, Wei-Hung Lin, Ih-Jen Su, and Yao Chang* (Jun. 2012). Epstein-Barr virus latent membrane protein 2A promotes invasion of nasopharyngeal carcinoma cells through ERK/Fra-1-mediated induction of matrix metalloproteinase 9. Journal of Virology, 86(12):6656-6667. doi:10.1128/JVI.00174-12.

4.          Chien-Hsun Lee, Tzu-Hao Yeh, Hsiao-Ching Lai, Shih-Yi Wu, Ih-Jen Su, Kenzo Takada, and Yao Chang* (Jul. 2011). Epstein-Barr virus Zta-induced immunomodulators from nasopharyngeal carcinoma cells upregulate interleukin-10 production from monocytes. Journal of Virology, 85(14):7333-7342. doi:10.1128/JVI.00182-11.

5.          Cheng-Chih Huang, Jenn-Ren Hsiao, Ming-Wei Yang, Yuan-Hua Wu, Keng-Fu Hsu, Yao Chang, Chaio-Wei Chen, Sen-Tien Tsai, Hsuan-Pei Wei, and Ying-Tai Jin (Jul. 2011). Human papilloma virus detection in neoplastic and non-neoplastic nasopharyngeal tissues in Taiwan. Journal of Clinical Pathology, 64(7):571-577. doi:10.1136/jcp.2010.087742.

6.          Ying-Fan Chen, Chao-Ling Tung, Yao Chang, Wen-Chi Hsiao, Ih-Jen Su, and Sunny Sun (Apr. 2011). Analysis of global methylation using a Zta-expressing nasopharyngeal carcinoma cell line. Genomics, 97(4):205-213. doi:10.1016/j.ygeno.2010.12.003.

7.          Kung-Chao Chang, Paul Chih-Hsueh Chen, Ya-Ping Chen, Yao Chang, and Ih-Jen Su (Jan. 2011). Dominant expression of survival signals of endoplasmic reticulum stress response in Hodgkin lymphoma. Cancer Science, 102(1):275-281. doi:10.1111/j.1349-7006.2010.01765.x.

8.          Sheng-Yen Huang, Chih-Yeu Fang, Ching-Hwa Tsai, Yao Chang, Kenzo Takada, Tsuey-Ying Hsu, and Jen-Yang Chen (Dec. 2010). N-methyl-N’-nitro-N-nitrosoguanidine induces and cooperates with 12-O-tetradecanoylphorbol-1,3-acetate/sodium butyrate to enhance Epstein-Barr virus reactivation and genome instability in nasopharyngeal carcinoma cells. Chemico-Biological Interactions, 188(3):623-634. doi:10.1016/j.cbi.2010.09.020.

9.          Mei-Chi Hsu, Jenn-Ren Hsiao, Kung-Chao Chang, Yuan-Hua Wu, Ih-Jen Su, Ying-Tai Jin, and Yao Chang* (Oct. 2010). Increase of programmed death-1-expressing intratumoral CD8 T cells predicts a poor prognosis for nasopharyngeal carcinoma. Modern Pathology, 23(10):1393-1403. doi:10.1038/modpathol.2010.130.

10.      Hsiao-Ching Lai, Jenn-Ren Hsiao, Chaio-Wei Chen, Shih-Yi Wu, Chien-Hsun Lee, Ih-Jen Su, Kenzo Takada, and Yao Chang* (Sep. 2010). Endogenous latent membrane protein 1 in Epstein-Barr virus-infected nasopharyngeal carcinoma cells attracts T lymphocytes through upregulation of multiple chemokines. Virology, 405(2):464-473. doi:10.1016/j.virol.2010.06.037.

11.      Jiin-Tarng Wang, Yu-Chia Chuang, Kun-Liang Chen, Chih-Chung Lu, Shin-Lian Doong, Hsu-Hsiang Cheng, Ya-Ling Chen, Ting-Yun Liu, Yao Chang, Chia-Hung Han, Sheng-Wen Yeh, and Mei-Ru Chen (Sep. 2010). Characterization of Epstein-Barr virus BGLF4 kinase expression control at the transcriptional and translational levels. Journal of General Virology, 91(9):2186-2196. doi:10.1099/vir.0.019729-0.

12.      Jenn-Ren Hsiao, Yao Chang#, Yuh-Ling Chen, Su-Huei Hsieh, Keng-Fu Hsu, Chun-Fu Wang, Sen-Tien Tsai, and Ying-Tai Jin (Feb. 2010). Cyclic αvβ6-targeting peptide selected from biopanning with clinical potential for head and neck squamous cell carcinoma. Head & Neck, 32(2):160-172. doi:10.1002/hed.21166.

13.      Wen-Chuan Hsieh, Bau-Shin Lan, Yi-Ling Chen, Yao Chang, Huai-Chia Chuang, and Ih-Jen Su (Feb. 2010). Efficacy of peroxisome proliferator activated receptor agonist in the treatment of virus-associated haemophagocytic syndrome in a rabbit model. Antiviral Therapy, 15(1):71-81. doi:10.3851/IMP1490.

14.      Kung-Chao Chang, Yao Chang, Dan Jones, and Ih-Jen Su (Jul. 2009). Aberrant expression of cyclin A correlates with morphogenesis of Reed-Sternberg cells in Hodgkin lymphoma. American Journal of Clinical Pathology, 132(1):50-59. doi:10.1309/AJCPBDFR5L5UOAUZ.

15.      Jenn-Ren Hsiao, Kung-Chao Chang, Chaio-Wei Chen, Shih-Yi Wu, Ih-Jen Su, Mei-Chi Hsu, Ying-Tai Jin, Sen-Tien Tsai, Kenzo Takada, and Yao Chang* (May 2009). Endoplasmic reticulum stress triggers XBP-1-mediated up-regulation of an EBV oncoprotein in nasopharyngeal carcinoma. Cancer Research, 69(10):4461-4467. doi:10.1158/0008-5472.CAN-09-0277.

16.      Chih-Yeu Fang, Chia-Huei Lee, Chung-Chun Wu, Yu-Ting Chang, Shu-Ling Yu, Sheng-Ping Chou, Ping-Ting Huang, Chi-Long Chen, Jia-Woei Hou, Yao Chang, Ching-Hwa Tsai, Kenzo Takada, and Jen-Yang Chen (May 2009). Recurrent chemical reactivations of EBV promotes genome instability and enhances tumor progression of nasopharyngeal carcinoma cells. International Journal of Cancer, 124(9):2016-2025. doi:10.1002/ijc.24179.

17.      Chung-Pei Lee, Yu-Hao Huang, Su-Fang Lin, Yao Chang, Yu-Hsin Chang, Kenzo Takada, and Mei-Ru Chen (Dec. 2008). Epstein-Barr virus BGLF4 kinase induces disassembly of the nuclear lamina to facilitate virion production. Journal of Virology, 82(23):11913-11926. doi:10.1128/JVI.01100-08.

18.      Huai-Chia Chuang, Ju-Ming Wang, Wen-Chuan Hsieh, Yao Chang, and Ih-Jen Su (Nov. 2008). Up-regulation of activating transcription factor-5 suppresses SAP expression to activate T cells in hemophagocytic syndrome associated with Epstein-Barr virus infection and immune disorders. American Journal of Pathology, 173(5):1397-1405. doi:10.2353/ajpath.2008.080440.

19.      Chia-Huei Lee, Chih-Yeu Fang, Jim Jinn-Chyuan Sheu, Yao Chang, Kenzo Takada, and Jen-Yang Chen (Aug. 2008). Amplicons on chromosome 3 contain oncogenes induced by recurrent exposure to 12-O-tetradecanoylphorbol-13-acetate and sodium n-butyrate and Epstein-Barr virus reactivation in a nasopharyngeal carcinoma cell line. Cancer Genetics and Cytogenetics, 185(1):1-10. doi:10.1016/j.cancergencyto.2008.03.014.

20.      Meichi Hsu, Shih-Yi Wu, Shih-Shin Chang, Ih-Jen Su, Ching-Hwa Tsai, Siao-Jing Lai, Ai-Li Shiau, Kenzo Takada, and Yao Chang* (Apr. 2008). Epstein-Barr virus lytic transactivator Zta enhances chemotactic activity through induction of interleukin-8 in nasopharyngeal carcinoma cells. Journal of Virology, 82(7):3679-3688. doi:10.1128/JVI.02301-07.

21.      Wen-Chuan Hsieh, Yao Chang, Mei-Chi Hsu, Guan-Chung Hsiao, Huai-Chia Chuang, and Ih-Jen Su (May 2007). Emergence of anti-red blood cell antibodies triggers red cell phagocytosis by activated macrophages in a rabbit model of Epstein-Barr virus-associated hemophagocytic syndrome. American Journal of Pathology, 170(5):1629-1639. doi:10.2353/ajpath.2007.060772.

22.      Huai-Chia Chuang, Jong-Ding Lay, Shuang-En Chuang, Wen-Chuan Hsieh, Yao Chang, and Ih-Jen Su (May 2007). Epstein-Barr virus (EBV) latent membrane protein-1 down-regulates tumor necrosis factor-a (TNF-a) receptor-1 and confers resistance to TNF-a-induced apoptosis in T cells: implication for the progression to T-cell lymphoma in EBV-associated hemophagocytic syndrome. American Journal of Pathology, 170(5):1607-1617. doi: 10.2353/ajpath.2007.061026.

23.      Yao Chang, Heng-Huan Lee, Yu-Te Chen, Jean Lu, Shih-Yi Wu, Chaio-Wei Chen, Kenzo Takada, and Ching-Hwa Tsai (Aug. 2006). Induction of the early growth response-1 gene by Epstein-Barr virus lytic transactivator Zta. Journal of Virology, 80(15):7748-7755. doi:10.1128/JVI.02608-05.

24.      Huai-Chia Chuang, Jong-Ding Lay, Wen-Chuan Hsieh, Hui-Ching Wang, Yao Chang, Shuang-En Chuang, and Ih-Jen Su (Nov. 2005). Epstein-Barr virus LMP1 inhibits the expression of SAP gene and upregulates Th1 cytokines in the pathogenesis of hemophagocytic syndrome. Blood, 106(9):3090-3096. doi:10.1182/blood-2005-04-1406.

25.      Yao Chang, Tso-Ching Lee, Jian-Chiuan Li, Ting-Lung Lai, Huey-Huey Chua, Chi-Long Chen, Shin-Lian Doong, Chen-Kung Chou, Tzung-Shiahn Sheen, and Ching-Hwa Tsai (Oct. 2005). Differential expression of osteoblast-specific factor 2 and polymeric immunoglobulin receptor genes in nasopharyngeal carcinoma. Head & Neck, 27(10):873-882. doi:10.1002/hed.20253.

26.      Tsuey-Ying Hsu, Yao Chang, Pei-Wen Wang, Mei-Ying Liu, Mei-Ru Chen, Jen-Yang Chen, and Ching-Hwa Tsai (Feb. 2005). Reactivation of Epstein-Barr virus can be triggered by an Rta protein mutated at the nuclear localization signal. Journal of General Virology, 86(2):317-322. doi:10.1099/vir.0.80556-0.

27.      Yao Chang, Heng-Huan Lee, Shih-Shin Chang, Tsuey-Ying Hsu, Pei-Wen Wang, Yu-Sun Chang, Kenzo Takada, and Ching-Hwa Tsai (Dec. 2004). Induction of Epstein-Barr virus latent membrane protein 1 by a lytic transactivator Rta. Journal of Virology, 78(23):13028-13036. doi:10.1128/JVI.78.23.13028-13036.2004.

28.      Yao Chang, Shih-Shin Chang, Heng-Huan Lee, Shin-Lian Doong, Kenzo Takada, and Ching-Hwa Tsai (Jun. 2004). Inhibition of the Epstein-Barr virus lytic cycle by Zta-targeted RNA interference. Journal of General Virology, 85(6):1371-1379. doi:10.1099/vir.0.79886-0.

29.      Yao Chang, Sou-De Cheng, and Ching-Hwa Tsai (Feb, 2002). Chromosomal integration of Epstein-Barr virus genomes in nasopharyngeal carcinoma cells. Head & Neck, 24(2):143-150. doi:10.1002/hed.10039.

30.      Jean Lu, Shao-Yin Chen, Huey-Huey Chua, Yu-Sheng Liu, Yu-Tzu Huang, Yao Chang, Jen-Yang Chen, Tzung-Shiahn Sheen, and Ching-Hwa Tsai (Aug. 2000). Upregulation of TKT tyrosine kinase by the Epstein-Barr virus transactivator Zta. Journal of Virology, 74(16):7391-7399.

31.      Yao Chang, Che-Huang Tung, Yu-Tzu Huang, Jean Lu, Jen-Yang Chen, and Ching-Hwa Tsai (Oct. 1999). Requirement for cell-to-cell contact in Epstein-Barr virus infection of nasopharyngeal carcinoma cells and keratinocytes. Journal of Virology, 73(10):8857-8866.

32.      Yu-Tzu Huang, Tzung-Shiahn Sheen, Chi-Long Chen, Jean Lu, Yao Chang, Jen-Yang Chen, and Ching-Hwa Tsai (Apr. 1999). Profile of cytokine expression in nasopharyngeal carcinomas: a distinct expression of interleukin-1 in tumor and CD4+ T cells. Cancer Research, 59(7):1599-1605.

33.      Tzung-Shiahn Sheen, Jeng-Yuh Ko, Yen-Liang Chang, Yuan-Shau Chang, Yu-Tzu Huang, Yao Chang, Ching-Hwa Tsai, and Mow-Ming Hsu (Dec. 1998). Nasopharyngeal swab and PCR for the screening of nasopharyngeal carcinoma in endemic area: a good supplement to the serologic screening. Head & Neck, 20(8):732-738.

34.      Yao Chang, Tzung-Shiahn Sheen, Jean Lu, Yu-Tzu Huang, Jen-Yang Chen, Czau-Siung Yang, and Ching-Hwa Tsai (Jun. 1998). Detection of transcripts initiated from two viral promoters (Cp and Wp) in Epstein-Barr virus-infected nasopharyngeal carcinoma cells and biopsies. Laboratory Investigation, 78(6):715-726.

Presentations: (*oral presentation)

1.           Yao Chang* (Nov. 2012). Matrix metalloproteinase 9 is a convergent effector for EBV-induced cell invasion. Asia-Pacific Congress on Virus Related Malignancies. Taipei, Taiwan.

2.           Yao Chang*, Chien-Hsun Lee, Tzu-Hao Yeh, Hsiao-Ching Lai, Shih-Yi Wu, and Ih-Jen Su (Jun. 2011). Potential roles of Epstein-Barr virus reactivation in local immune suppression of nasopharyngeal carcinoma. 5th International Symposium on Nasopharyngeal Carcinoma. Penang, Malaysia.

3.           Yao Chang* (May 2011). Effects of Epstein-Barr virus on the tumor microenvironment of nasopharyngeal carcinoma. The 8th Across the Taiwan Strait Symposium on Cell Biology. Tainan, Taiwan.

4.           Yao Chang* (Dec. 2010). Interaction among Epstein-Barr virus, tumor cells and immune cells in cancer development. NHRI-NTHU Joint Research Conference. Miaoli, Taiwan.

5.           Chien-Hsun Lee, Tzu-Hao Yeh, Hsiao-Ching Lai, Shih-Yi Wu, and Yao Chang (Sep. 2010). A novel way of EBV to upregulate production of human interleukin-10. 14th Biennial Conference of the International Association for Research on Epstein-Barr Virus and Associated Diseases. Birmingham, UK.

6.           Mei-Chi Hsu, Jenn-Ren Hsiao, Chaio-Wei Chen, and Yao Chang* (Jun. 2009). Association of an immunosuppressive marker with prognosis of nasopharyngeal carcinoma. 4th International Symposium on Nasopharyngeal Carcinoma. Marrakech, Morocco.

7.           Yao Chang*, Jenn-Ren Hsiao, Chaio-Wei Chen, Shih-Yi Wu, Mei-Chi Hsu, and Ih-Jen Su (Nov. 2008). Induction of Epstein-Barr virus latent membrane protein 1 by endoplasmic reticulum stress in nasopharyngeal carcinoma cells. 13th Biennial Conference of the International Association for Research on Epstein-Barr Virus and Associated Diseases. Guangzhou, China.

8.           Yao Chang* (Jul. 2007). Upregulation of interleukin-8 by Epstein-Barr virus lytic transactivator Zta in nasopharyngeal carcinoma cells. East-West Symposium on Nasopharyngeal Carcinoma. Sunshine Coast, Australia.

9.           Yao Chang* (May 2007). Regulation of cellular genes by Epstein-Barr virus lytic transactivator Zta. Conference of Advanced Virus Research in Tzu Chi University. Hualien, Taiwan.

10.       Yao Chang, Yu-Te Chen, Heng-Huan Lee, Shih-Yi Wu, Chaio-Wei Chen, and Ching-Hwa Tsai (Jul. 2006). Inter-regulation of Zta, Rta, and Egr-1 as a positive-feedback network in spontaneous reactivation of Epstein-Barr virus. 12th Biennial Conference of the International Association for Research on Epstein-Barr Virus and Associated Diseases. Boston, USA.

11.       Yao Chang*, Yu-Te Chen, Heng-Huan Lee, Shih-Yi Wu, Chaio-Wei Chen, and Ching-Hwa Tsai (May 2006). Early growth response-1 gene is induced by Zta and involved in reactivation of Epstein-Barr virus. 6th NHRI Conference on Tumor-Associated Herpesviruses. Miaoli, Taiwan.

12.       Yao Chang, Yu-Te Chen, Heng-Huan Lee, Shih-Shin Chang, and Ching-Hwa Tsai. (Apr. 2005). Epstein-Barr virus Zta-mediated induction of Egr-1 gene. The NHRI 10th Anniversary and Campus Grand Opening. Miaoli, Taiwan.

13.       Yao Chang*, Heng-Huan Lee, Shih-Shin Chang, and Ching-Hwa Tsai (Sep. 2004). Induction of latent membrane protein 1 during Epstein-Barr virus reactivation. 11th Biennial Conference of the International Association for Research on Epstein-Barr Virus and Associated Diseases. Regensburg, Germany.

14.       Yao Chang*, Heng-Huan Lee, Shih-Shin Chang, Tsuey-Ying Hsu, and Ching-Hwa Tsai (Jun. 2004). Rta-mediated induction of Epstein-Barr virus latent membrane protein 1. 5th NHRI Conference on Tumor-Associated Herpesviruses. Taoyuan, Taiwan.

15.       Yao Chang, Jian-Chiuan Li, Ting-Lung Lai, Huey-Huey Chua, Jen-Yang Chen, and Ching-Hwa Tsai (Jul. 2002). Identification of two cellular genes differentially expressed in nasopharyngeal carcinoma biopsies. 10th International Symposium on Epstein-Barr Virus and Associated Malignant Diseases. Cairns, Australia.

16.       Yao Chang*, Sou-De Cheng, and Ching-Hwa Tsai (May 2002). Persistence of Epstein-Barr virus in nasopharyngeal carcinoma cells by chromosomal integration. 4th NHRI Conference on Nasopharyngeal Carcinoma and Herpesvirus-associated Diseases. Taoyuan, Taiwan.

 



更新日期:2016-02-24

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