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Horng Yunn Dou

杜鴻運 副研究員
感染症與疫苗研究所
連絡電話:037-246166 ext 35529
E-mail:hydou@nhri.org.tw

學歷


1989 - 1998     博士, 微生物免疫學研究所, 國立陽明大學, -
1987 - 1989     碩士, 微生物免疫學研究所, 國防醫學院, -

經歷

2012/06 - 2006     副研究員, 感染症與疫苗研究所, 國家衛生研究院, -
2005 - 2012/06     助研究員, 疫苗研發中心, 國家衛生研究院, -
2005 - 2005     資深研究員, -, 賽德醫藥科技公司, -
2002 - 2003     訪問學者, 生物技術研究所, 加拿大國家研究委員會, -
1999 - 2000     訪問學者, 微生物研究所, 美國愛恩斯坦醫學院, -
1996 - 2005     主任, 檢驗科, 臺北市立慢性病防治醫院, -
1985 - 1996     醫檢師, 檢驗科, 臺北市仁愛醫院, -
1981 - 1985     醫檢師, 檢驗科, 省立桃園醫院, -
1979 - 1981     陸軍少尉, -, 兵役, -

Honors & Awards


2013 衛生福利部102年防疫績優個人獎
2000 行政院衛生署結核病防治體系重建委員會實驗診斷組專家
1999 - 2000 傅爾布萊特獎學金交換學者獎學金至美國紐約市愛恩斯坦醫學院
1989 微生物免疫學會獎學金
1988 國防醫學院學業績優獎學金
1987 國防醫學院學業績優獎學金

行政兼職

 



Research Interests

Mycobacterology laboratory research will include TB immuno-pathogenesis, primarily TB genomic study, and recombinant BCG or TB vaccine development. TB research is still needed to provide a solid foundation of understanding of the pathogenesis and development of drug resistance in TB. Subjects including: 1.Surveillance of epidemiology and drug resistance of TB in Taiwan. 2.Understanding the epidemiology that contribute to the development and spread of Drug resistant strains of Mtb 3.Study the host immunity and markers that signal transition from latent to active TB. 4.Understanding the basic biology and immunology of host and pathogen that underlie the development and spread of drug-resistant strains of Mtb. 5.Identification of candidate virulence factor for the pathogenesis of MTB infection and vaccine development

Research Activities & Accomplishment

In general, the public health impact of vaccination programs with new TB vaccines will be dependent crucially on (i) the diversity of circulating Mtb strains, (ii) the mechanisms of competition between strains, and (iii) the strain specificity of these vaccines. In this study, we have revealed the distribution of MTB in Taiwan is closely associated with the ethnicity and migratory population at different historical periods. These results have implications for tuberculosis control efforts, especially for the development of new vaccines. 1.To study the molecular epidemiology of MTB in Taiwan. 2.To fully explore gene variability within the clinical isolate. We will perform the complete genome sequencing and annotation of a clinical isolate of M. tuberculosis strain from different ethnic population, in an attempt to correlate genotypic changes with strain phenotype. 3.To modify BCG by recombinant DNA technology to produce a new live vaccine that expresses immunodominant antigen and/or cytokine with efficacy superior to that of BCG.

Publications

Publications: (* Dou HY as corresponding author)

1.      Chen YY, Chang JR, Huang WF, Kuo SC, Yeh JJ, Lee JJ, Jang CS, Sun JR, Chiueh TS, Su IJ, Dou HY*. Molecular epidemiology of Mycobacterium tuberculosis in aboriginal peoples of Taiwan, 2006-2011. J Infect. 2013 Dec 24. pii: S0163-4453(13)00380-0

2.      Huang L, Chen TL, Lee YT, Lee MH, Kuo SC, Yu KW, Dou HY, Fung CP. Risk factors for imipenem-nonsusceptible Acinetobacter nosocomialis bloodstream infection. J Microbiol Immunol Infect. 2013 Apr 30. pii: S1684-1182(13)00028-5.

3.      Lee MH, Chen TL, Lee YT, Huang L, Kuo SC, Yu KW, Hsueh PR, Dou HY, Su IJ, Fung CP. Dissemination of multidrug-resistant Acinetobacter baumannii carrying BlaOxA-23 from hospitals in central Taiwan. J Microbiol Immunol Infect. 2013 Dec;46(6):419-24.

4.      Chang JR, Chen YY, Huang TS, Huang WF, Kuo SC, Tseng FC, Su IJ, Lin CH, Chen YS, Sun JR, Chiueh TS, Dou HY*. Clonal expansion of both modern and ancient genotypes of Mycobacterium tuberculosis in southern Taiwan. PLoS One. 2012;7(8):e43018.

5.      Chen YY, Chang JR, Huang WF, Kuo SC, Su IJ, Sun JR, Chiueh TS, Huang TS, Chen YS, Dou HY*. Genetic diversity of the Mycobacterium tuberculosis Beijing family based on SNP and VNTR typing profiles in Asian countries. PLoS One. 2012;7(7):e39792.

6.      Weng CY, Ho CM, Dou HY, Ho MW, Lin HS, Chang HL, Li JY, Lin TH, Tien N, Lu JJ. Molecular typing of Mycobacterium tuberculosis isolated from adult patients with tubercular spondylitis. J Microbiol Immunol Infect. 2013 Feb;46(1):19-23.

7.      de Beer JL, Kremer K, Ködmön C, Supply P, van Soolingen D; Global Network for the Molecular Surveillance of Tuberculosis 2009. First worldwide proficiency study on variable-number tandem-repeat typing of Mycobacterium tuberculosis complex strains. J Clin Microbiol. 2012 Mar;50(3):662-9.

8.      Lin CW, Su IJ, Chang JR, Chen YY, Lu JJ, Dou HY*. Recombinant BCG coexpressing Ag85B, CFP10, and interleukin-12 induces multifunctional Th1 and memory T cells in mice. APMIS. 2012 Jan;120(1):72-82.

9.      Huang SF, Su WJ, Dou HY, Feng JY, Lee YC, Huang RM, Lin CH, Hwang JJ, Lee JJ, Yu MC. Association of Mycobacterium tuberculosis genotypes and clinical and epidemiological features - a multi-center study in Taiwan. Infect Genet Evol. 2012 Jan;12(1):28-37.

10.  Sun JR, Dou HY, Lee SY, Chiueh TS, Lu JJ. Epidemiological studies of Beijing strains of Mycobacterium tuberculosis from Taipei and other Asian cities based on MIRU profiles. APMIS. 2011 Sep;119(9):581-7.

11.  Chang JT, Dou HY, Yen CL, Wu YH, Huang RM, Lin HJ, Su IJ, Shieh CC. Effect of type 2 diabetes mellitus on the clinical severity and treatment outcome in patients with pulmonary tuberculosis: a potential role in the emergence of multidrug-resistance. J Formos Med Assoc. 2011 Jun;110(6):372-81.

12.  Dou HY, Huang SC, Su IJ*. Prevalence of Mycobacterium tuberculosis in Taiwan: A Model for Strain Evolution Linked to Population Migration. Int J Evol Biol. 2011 Jan 17;2011:937434.

13.  Chang JR, Lin CH, Tsai SF, Su IJ, Tseng FC, Chen YT, Chiueh TS, Sun JR, Huang TS, Chen YS, Dou HY*. Genotypic analysis of genes associated with transmission and drug resistance in the Beijing lineage of Mycobacterium tuberculosis. Clin Microbiol Infect. 2011 Sep;17(9):1391-6.

14.  Lee SS, Chou KJ, Dou HY, Huang TS, Ni YY, Fang HC, Tsai HC, Sy CL, Chen JK, Wu KS, Wang YH, Lin HH, Chen YS. High prevalence of latent tuberculosis infection in dialysis patients using the interferon-gamma release assay and tuberculin skin test. Clin J Am Soc Nephrol. 2010 Aug;5(8):1451-7.

15.  Dou HY, Lu JJ, Lin CW, Chang JR, Sun JR, Su IJ*. Utility and evaluation of new variable-number tandem-repeat systems for genotyping mycobacterial tuberculosis solates. J Microbiol Methods. 2009 Apr;77(1):127-9.

16.  Dou HY, Tseng FC, Lin CW, Chang JR, Sun JR, Tsai WS, Lee SY, Su IJ, Lu JJ. Molecular epidemiology and evolutionary genetics of Mycobacterium tuberculosis in Taipei. BMC Infect Dis. 2008 Dec 22;8:170. doi: 10.1186/1471-2334-8-170.

17.  Sun JR, Lee SY, Dou HY, Lu JJ. Using a multiplex polymerase chain reaction for the identification of Beijing strains of Mycobacterium tuberculosis. Eur J Clin Microbiol Infect Dis. 2009 Jan;28(1):105-7.Dou HY, Tseng FC, Lu JJ, Jou R, Tsai SF, Chang JR, Lin CW, Miu WC, Su IJ*. Associations of Mycobacterium tuberculosis genotypes with different ethnic and migratory populations in Taiwan. Infect Genet Evol. 2008 May;8(3):323-30.

 

Non peer reviewed publication

1.    蘇益仁,杜鴻運,齊嘉鈺,張雅雯。台灣結核病防治的幾個關鍵議題-國家衛生研究院第一屆結核病研討會後記(2007第十七, 第三期.)

2.   杜鴻運, 蘇益仁。台灣結核菌在各族群間的分子流行病學。2008感控雜誌第十八卷第二期.

3.   林智偉,張嘉茹,杜鴻運,肺結核的分子流行病學現代觀。2008感控雜誌第十八卷第五期.

4.   探討台北地區肺結核流行現況與其基因演化過程2009感控雜誌第十九卷第五期.

Books

1.結核菌檢驗手冊,2002,行政院衛生署疾病管制局編印(第一版ISBN 957-01-0645-x),陸坤泰、杜鴻運、吳竹蘭、彭健芳、薛博仁、蔡文城、鄧麗珍、簡修平、謝文祥、蘇維鈞。

2.研究倫理教學手冊,2009, 編輯委員,財團法人黃達夫醫學教育促進基金會(第一版ISBN978-0-16-072285-1)

3.IACUC handbook of NHRI,1st version.2011,編輯委員,財團法人國家衛生研究院。

 



Patents

專利名稱 發明人 日期 國家 編號
RECOMBINANT BCG STRAINS WITH ENHANCED ABILITY TO INHIBIT INTRACELLULAR MYCOBACTERIAL GROWTH Horng -Yunn Dou May 9,2013 US 20130115240A1
Primers, snp markers and method for genotyping mycobacterium tuberculosis Shih-feng Tsai, Chien-hsing Lin, Horng-yunn Dou Jun 12,2014 US 20140162260A1

Lab Member

姓 名 職 稱 分機 E-mail
楊秀菊 博士後研究員 35531 shiujuy1016@nhri.org.tw
許志豪 研究助理 35531 vanes1126@nhri.org.tw
張嘉茹 研究助理 35531 950606@nhri.org.tw

更新日期:2019-06-03

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