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Tse-Hua Tan

譚澤華 特聘研究員
免疫醫學研究中心
連絡電話:037-246166轉37601
傳真電話:037-586642
E-mail:ttan@nhri.org.tw

學歷


1987 - 1989     Postdoctoral Fellow, Cancer Research Institute Postdoctoral Fellowship, The Rockefeller University, USA
1982 - 1987     Ph.D., Molecular Biology, Princeton University, USA
1975 - 1980     B.S., Chemistry, National Taiwan University, Taiwan

經歷

2007 - present     Distinguished Investigator and Director, Immunology Research Center, National Health Research Institutes, Taiwan
2000 - present     Professor (Tenured), Department of Immunology (Department of Pathology & Immunology, 2010-), Baylor College of Medicine, USA
1997 - 2000     Associate Professor (Tenured), Department of Microbiology & Immunology, Baylor College of Medicine, USA
1992 - 1997     Assistant Professor, Department of Microbiology & Immunology, Baylor College of Medicine, USA
1989 - 1992     Principal Investigator, Laboratory of Experimental Immunology, National Cancer Institute-Frederick Cancer Research & Development Center, USA

Honors & Awards


1996 American Cancer Society Junior Faculty Research Award, USA (declined)
1996 - 2001 Leukemia Society of America Scholar, USA (1996-2001)
1988 - 1990 Cancer Research Institute Fellow, USA (1988-1990)
1982 - 1987 Princeton University Prize Fellowship (1982-1987)
1979 - 1980 Natl. Taiwan University Presidential Awards(President
1978 - 1980 Chinese Cultural & Natural Science Scholarship, Govt. of Taiwan (1978-1980)

行政兼職

Director

 



Research Interests

 

JNK-MAPK Kinases and Phosphatases in Lymphocyte Signaling, Autoimmunity, and Inflammation-induced Cancer, Type 2 Diabetes and Obesity

       Dr. Tan did seminal works leading to the discovery of the role of p53 as a tumor suppressor and the role of JNK in apoptosis.

       Dr. Tan is an experienced investigator in studying the functions and regulation of the JNK pathway in lymphocyte signal transduction and immune regulation using biochemical and knockout mouse approaches. In particular, Dr. Tan’s group is among the first to demonstrate the critical role of JNK in apoptosis. His laboratory proposed a novel hypothesis that differences in the duration of JNK induction will lead to disparate outcomes of cell proliferation versus apoptosis. This study unveiled the important roles and regulation of JNK in apoptosis signaling pathways. Dr. Tan’s team and his colleagues have cloned and characterized 12 novel signaling molecules particularly MAP4K family kinases and protein phosphatases that regulate the JNK-MAPK cascade. In particular, he discovered novel roles of three MAP4Ks (HPK1/MAP4K1, GLK/MAP4K3, HGK/MAP4K4) in T-cell signaling, autoimmunity, inflammation, and obesity/type 2 diabetes. Dr. Tan’s research team also identified two protein phosphatases (PP4 and JKAP) that stimulate the JNK kinase cascade. They have generated JKAP knockout mice and T-cell specific PP4 conditional knockout mice and revealed JKAP and PP4’s functions in cytokine signaling and T-cell development/preTCR signaling. Dr. Tan’s current research focuses on studying the roles of various JNK-MAPK kinases and phosphatases in lymphocyte signaling, autoimmunity, and inflammation-induced human diseases, including cancer, type 2 diabetes and obesity.



Research Activities & Accomplishment

Dr. Tan is an accomplished investigator in molecular immunology and signal transduction. He is a leader in studying the functions and regulation of the JNK pathway in T-cell signal transduction and immune regulation using biochemical and gene knockout mouse approaches. In particular, Dr. Tan’s group is the first to demonstrate the critical role of JNK in T-cell apoptosis. His laboratory proposed a novel hypothesis that differences in the duration of JNK induction will lead to disparate outcomes of cell proliferation versus apoptosis. The study is a major breakthrough in unveiling the important roles and regulation of JNK in apoptosis signaling pathways. Dr. Tan’s team has cloned and characterized 12 novel signaling molecules particularly MAP4K family kinases (HPK1, HGK, GLK) and protein phosphatases (JKAP, PP4) that regulate the JNK-MAPK cascade. In addition, Dr. Tan’s Ph.D. thesis research has made a seminal discovery of the function of the p53 tumor suppressor gene.

HONORS

1978-1980

Chinese Cultural & Natural Science Scholarship (Govt. of Taiwan)

1979-1980

Natl. Taiwan University Presidential Awards (President's Book Coupon Awards)

1982-1987

Prize Fellowship, Princeton University

1988-1990

Postdoctoral Fellowship, Cancer Research Institute, USA

1996

Junior Faculty Research Award, American Cancer Society, USA (declined)

1996-2001

Scholar Award, Leukemia Society of America, USA

1997-1998

President, Society of Chinese Bioscientists in America (SCBA)-Texas Chapter

2000-2001

Member, NCI Special Emphasis Panel on “Molecular Target Drug Discovery for Cancer”, National Institutes of Health (NIH)

2001-2002

Regular Member, Pathology C (PTHC) Study Section, NIH

2002-2006

Founding Member, Cancer Molecular Pathobiology Study Section, National Institutes of Health (NIH), USA

2010-2013

Councilor, Society of Chinese Bioscientists in America (SCBA)

2009-present

Editor, Journal of Signal Transduction 

2009-present

Editor, American Journal of Translation Medicine

2011-present

Editor, Journal of Cell & Bioscience

2012

The 22th Wang Min-Ning Memorial Award for Outstanding Contribution to the Medical Science and Technology Development, National Health, and Society, Taiwan

2014

Taiwan Bio-Development Foundation (TBF) Endowment-TBF Chair in Biotechnology

2016-present

Associate Editor, Journal of Biomedical Science, Taiwan

2016

2016 Hou Jindui Distinguished Honor Award (侯金堆傑出榮譽獎:基礎科學生物類)

2016

2016 Outstanding Research Award, Ministry of Science and Technology, R.O.C. (科技部105年度傑出研究獎)

 

 



Publications

SELECTED PUBLICATIONS (from more than 100 peer-reviewed papers)

1.  T.‑H. Tan, J. Wallis, and A.J. Levine. 1986. Identifica­tion of the p53 protein domain involved in formation of the simian virus 40 large T‑antigen‑p53 protein complex. J. Virol. 59:574‑583.  [ Abstract ]

2.  Finlay, C.A., P.W. Hinds, T.-H. Tan, D. Eliyahu, M. Oren, and A.J. Levine 1988. Activating mutations for transformat­i­on by p53 produce a gene product that forms an hsc70‑p53 complex with an altered half‑life. Mol. Cell. Biol. 8:531‑539. [ Abstract ]

3.  Ruben, S., H. Poteat, T.-H. Tan, K. Kawakami, R. Roeder, W. Haseltine, and C.A. Rosen. 1988. Cellular transcription factors and regulation of IL‑2 receptor gene expression by HTLV‑I tax gene product. Science 241:89‑92. [ Abstract ]

4.  Tan, T.‑H., M. Horikoshi, and R.G. Roeder 1989. Purifica­tion and characterization of multiple nuclear factors that bind to the TAX‑inducible enhancer within the human T‑cell leukemia virus type 1 long terminal repeat. Mol. Cell. Biol. 9:1733‑1745. [ Abstract ]

5.  Tan, T.‑H., R. Jia, and R.G. Roeder 1989. Utilization of signal transduction pathway by the human T-cell leukemia virus type I transcriptional activat­or tax. J. Virol. 63:3761-3768.  [ Abstract ]

6.  Tan, T.-H., G.P. Huang, A. Sica, P. Ghosh, H.A. Young, D.L. Longo, and N.R. Rice. 1992. kB site-dependent activation of the interleukin-2 receptor k-chain gene promoter by human c-Rel. Mol. Cell. Biol. 12:4067-4075. [ Abstract ]

7. Lai, J.-H., and T.-H. Tan. 1994. CD28 signaling causes a sustained down-regulation of IkB which can be prevented by the immunosuppressant rapamycin. J. Biol. Chem. 269:30077-30080. [ Abstract ]

8.  Bryan, R.G., Y. Li, J.-H. Lai, M. Van, N.R. Rice, R.R. Rich, and T.-H. Tan. 1994. Effect of CD28 signal transduction on c-Rel in human peripheral blood T cells. Mol. Cell. Biol. 14:7933-7942. [ Abstract ]

9.  Lai, J.-H., G. Horvath, J. Subleski, J. Bruder, P. Ghosh, and T.-H. Tan. 1995. RelA is a potent transcriptional activator of the CD28 response element within the interleukin 2 promoter. Mol. Cell. Biol. 15:4260-4271. [ Abstract ]

10.  Chen, Y.-R., C.F. Meyer, and T.-H. Tan. 1996. Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in g radiation-induced apoptosis. J. Biol. Chem. 271:631-634. [ Abstract ]

11.  Meyer, C.F., X. Wang, C. Chang, D. Templeton, and T.-H. Tan. 1996. Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating kB enhancer activation. J. Biol. Chem. 271:8971-8976. [ Abstract ]

12.  Hu, M.C.-T., W. Qiu, X. Wang, C.F. Meyer, and T.-H. Tan. 1996. Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade. Genes & Development 10:2251-2264. [ Abstract ]

13.  Wang, X.S., K. Diener, D. Jannuzzi, D. Trollinger, T.-H. Tan, H. Lichenstein, M. Zukowski, and Z. Yao. 1996. Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase. J. Biol. Chem. 271:31607-31611. [ Abstract ]

14.  Chen, Y.-R., X. Wang, D. Templeton, R.J. Davis, and T.-H. Tan. 1996. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and g radiation: duration of JNK activation may determine cell death and proliferation. J. Biol. Chem. 271:31929-31936. [ Abstract ]

15.  Diener, K., X.S. Wang, C. Chen, C.F. Meyer, G. Keesler, M. Zukowski, T.-H. Tan, and Z. Yao. 1997. Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase. Proc. Natl. Acad. Sci. USA 94:9687-9692. [ Abstract ]

16.  Wang, W., G. Zhou, M.C.-T. Hu, Z. Yao, and T.-H. Tan. 1997. Activation of the hematopoietic progenitor kinase-1 (HPK1)-dependent, stress-activated c-Jun N-terminal kinase (JNK) pathway by transforming growth factor b (TGF-b)-activated kinase (TAK1), a kinase mediator of TGF-b signal transduction. J. Biol. Chem. 272:22771-22775. [ Abstract ]

17.  Yao, Z., K. Diener, X.S. Wang, M. Zukowski, G. Matsumoto, G. Zhou, R. Mo, T. Sasaki, H. Nishina, C.C. Hui, T.-H. Tan, J.P. Woodgett, and J.M. Penninger. 1997. Activation of stress-activated protein kinases/c-Jun N-terminal protein kinases (SAPKs/JNKs) by a novel mitogen-activated protein kinase kinase (MKK7). J. Biol. Chem. 272:32378-32383. [ Abstract ]

18.  Chen, Y.-R., W. Wang, A.-N.T. Kong, and T.-H. Tan. 1998. Molecular mechanisms of c-Jun N-terminal kinase-mediated apoptosis induced by anticarcinogenic isothiocyanates. J. Biol. Chem. 273:1769-1775. [ Abstract ]

19.  Chen, Y.-R., and T.-H. Tan. 1998. Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin. Oncogene 17:173-178. [ Abstract ]

20.  Hu, M. C.-T., Q. Tang-Oxley, W.R. Qiu, Y.-P. Wang, K. A. Mihindukulasuriya, R. Afshar, and T.-H. Tan. 1998. Protein phosphatase X interacts with c-Rel and stimulates c-Rel/NF-kB activity. J. Biol. Chem. 273:33561-33565. [ Abstract ]

21.  Yao, Z., G. Zhou, X.S. Wang, A. Brown, K. Diener, H. Gan, and T.-H. Tan. 1999. A novel human STE20-related protein kinase, HGK, that specifically activates the c-Jun N-terminal kinase signaling pathway. J. Biol. Chem. 274:2118-2125. [ Abstract ]

22.  Ling, P., Z. Yao, C.F. Meyer, X.S. Wang, W. Oehl, S.M. Feller, and T.-H. Tan. 1999. Interaction of HPK1 with the adaptor proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase (JNK). Mol. Cell. Biol. 19:1359-1368. [ Abstract ]

23.  Hu, M.C.-T., Y.-p. Wang, A. Mikhail, W.R. Qiu, and T.-H. Tan. 1999. Murine p38-d mitogen-activated protein kinase, a developmentally regulated protein kinase that is activated by stress and proinflammatory cytokines. J. Biol. Chem. 274:7095-7102. [ Abstract ]

24.  Zhou, G., S.C. Lee, Z. Yao, and T.-H. Tan. 1999. Hematopoietic progenitor kinase 1 is a component of transforming growth factor b-induced c-Jun N-terminal kinase signaling cascade. J. Biol. Chem. 274:13133-13138. [ Abstract ]

25.  Wouten, M.W., M.L. Seibenhener, G. Zhou, M.L. Vandenplas, and T.-H. Tan. 1999. Overexpression of atypical PKC in PC12 cells enhances NGF responsiveness and survival through an NF-kB pathway. Cell Death Differ. 6:753-764. [ Abstract ]

26.  Hu, M.C.-T., Y.-p. Wang, W.R. Qiu, A. Mikhail, C.F. Meyer, and T.-H. Tan. 1999. Hematopoietic progenitor kinase-1 (HPK1) stress response signaling pathway activates IkB kinases (IKK-a/b) and IKK-b is a developmentally regulated protein kinase. Oncogene 18:5514-5524. [ Abstract ]

27.  Ensenat, D., Z. Yao, X.S. Wang, R. Kori, S.C. Lee, and T.-H. Tan. 1999. A novel SH3 domain-containing adaptor protein, HIP-55, that interacts with hematopoietic progenitor kinase 1 (HPK1). J. Biol. Chem. 274:33945-33950. [ Abstract ]

28.  Chen, Y.-R., G. Zhou, and T.-H. Tan. 1999. c-Jun N-terminal kinase (JNK) mediates apoptotic signaling induced by N-(4-hydroxyphenyl)retinamide. Mol. Pharmacol. 56:1271-1279. [ Abstract ]

29. Chen, Y.-R., C.F. Meyer, B. Ahmed, Z. Yao, and T.-H. Tan. 1999. Caspase-mediated cleavage and functional changes of hematopoietic progenitor kinase 1 (HPK1). Oncogene 18:7370-7377. [ Abstract ]

30. Chen, Y.-R., and T.-H. Tan. 2000. The c-Jun N-terminal kinase pathway and apoptotic signaling. Int. J. Oncology 16:651-662. (Review)  [ Abstract ]

31. Chen, Y.-R., A. Shrivastava, and T.-H. Tan. 2001. Down-regulation of the c-Jun N-terminal kinase (JNK) phosphatase M3/6 and activation of JNK by hydrogen peroxide and pyrrolidine dithiocarbamate (PDTC). Oncogene 20:367-374. [ Abstract ]

32. Ling, P., C.F. Meyer, L.P. Redmond, J.-W. Shui, B. Davis, R.R. Rich, M.C.-T. Hu, R.L. Wange, and T.-H. Tan. 2001. Involvement of hematopoietic progenitor kinase 1 in T-cell receptor signaling. J. Biol. Chem. 276:18908-18914. [ Abstract ]

33.  Zhou, G., K.A. Mihindukulasuria, R.A. MacCorkle-Chosnek, A. Van Hooser, M. C.-T. Hu, B.R. Brinkley, and T.-H. Tan. 2002. Protein phosphatase 4 is involved in tumor necrosis factor-a-induced activation of c-Jun N-terminal kinase. J. Biol. Chem. 277:6391-6398. [ Abstract ]

34.  Chen, A.J., G. Zhou, T. Juan, S.M. Colicos, J.P. Cannon, M. Cabriera-Hansen, C.F. Meyer, R. Jurecic, N.G. Copeland, D.J. Gilbert, N.A. Jenkins, F. Fletcher, T.-H. Tan*, and J.W. Belmont*. 2002. The dual-specificity phosphatase JKAP specifically activates the c-Jun N-terminal kinase pathway. J. Biol. Chem. 277:36592-36601. [ Abstract ]

35.  Chen, Y.-R., J. Han, R. Kori, A.-N.T. Kong, and T.-H. Tan. 2002. Phenylethyl isothiocyanate induces apoptotic signaling via suppressing phosphatase activity against c-Jun N-terminal kinase. J. Biol. Chem. 277:39334-39342. [ Abstract ]

36.  Han, J., R. Kori, J.-W. Shui, Y.-R. Chen, Z. Yao, and T.-H. Tan. 2003. The SH3 domain-containing adaptor HIP-55 mediates c-Jun N-terminal kinase (JNK) activation in T cell receptor signaling. J. Biol. Chem. 278:52196-52202. [ Abstract ]

37.  MacCorkle, R.A. and T.-H. Tan. 2004. Inhibition of JNK2 disrupts anaphase and produces aneuploidy in mammalian cells. J. Biol. Chem. 279:40112-40121. [ Abstract ]

38.  Shui, J.-W., and T.-H. Tan. 2004. Germline transmission and efficient DNA recombination in mouse embryonic stem cells mediated by adenoviral-Cre transduction. Genesis 39:217-223. [ Abstract ]

39.  Mihindukulasuriya, K.A., G. Zhou, J. Qin, and T.-H. Tan. 2004. Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-a stimulation. J. Biol. Chem. 279:46588-46594. [ Abstract ]

40 Zhou, G., J.S. Boomer, and T.-H. Tan. 2004. Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1. J. Biol. Chem. 279:49551-49561. [ Abstract ]

41.  Zhang, X., Y. Ozawa, H. Lee, Y.-D. Wen, T.-H. Tan, B.E. Wadzinski, and E. Seto. 2005. Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4. Genes Dev. 19:827-839. [ Abstract ]

42.  Boomer, J.S., and T.-H. Tan. 2005. Functional interaction of HPK1 with adaptor proteins. J. Cell. Biochem. 95:34-44. (Review) [ Abstract ]

43.  Han, J., J.-W. Shui, X. Zhang, B. Zheng, S. Han, and T.-H. Tan. 2005. HIP-55 is important for T-cell proliferation, cytokine production and immune responses. Mol. Cell. Biol. 25:6869-6878. [ Abstract ]

44.  MacCorkle, R.A. and T.-H. Tan. 2005. Mitogen-activated protein kinases in cell-cycle control. Cell Biochem. Biophy. 43:451-462. (Review) [ Abstract ]

45.  Wang, J.-Y., C.-H. Lin, C.-H. Yang, T.-H. Tan, and Y.-R. Chen. 2006. Biological and biochemical characterization of a neuroendocrine-associated phosphatase (NEAP). J. Neurochem. 98:89-101. [ Abstract ]

46.  Shui, J.-W., M.C.-T. Hu, and T.-H. Tan. 2007. Conditional knockout mice reveal an essential role of protein phosphatase 4 in thymocyte development and pre-T-cell-receptor signaling. Mol. Cell. Biol. 27:79-91. [ Abstract ]

47.  Shui, J.-W., J.S. Boomer, J. Han, J. Xu, G.A. Dement, G. Zhou, and T.-H. Tan. 2007. HPK1 negatively regulates T cell receptor signaling and T cell-mediated immune responses. Nature Immunol. 8:84-91. [ Abstract ]

48.  Liang, J.J., H. Wang, A. Rashid, T.-H. Tan, R.F. Hwang, S.R. Hamilton, J.L. Abbruzzese, and D.B. Evans. 2008. Expression of MAP4K4 is associated with worse prognosis in patients with stage II pancreatic ductal adenocarcinoma. Clin. Cancer Res. 14:7043-7049. [ Abstract ]

49.  Onabajo, O.O., M.K. Seeley, A. Kale, B. Qualmann, M. Kessels, J. Han, T.-H. Tan, and W. Song. 2008. Actin binding protein 1 regulates B cell receptor-mediated antigen processing and presentation in response to B cell receptor activation. J. Immunol. 180:6685-6695. [ Abstract ]

50.  Wang, H., X. Song, C. Logsdon, G. Zhou, D.B. Evans, J.L. Abbruzzese, S.R. Hamilton, T.-H. Tan, and H. Wang. 2009. Proteasome-mediated degradation and functions of hematopoietic progenitor kinase 1 in pancreatic cancer. Cancer Res. 69:1063-1070. [ Abstract ]

51.  Tucker, K.L., W.J. Kaiser, A.L. Bergeron, H. Hu, J.F. Dong, T.-H. Tan, and J.M. Gibbins. 2009. Proteomic analysis of resting and thrombin-stimulated platelets reveals the translocation and functional relevance of HIP-55 in platelets. Proteomics 9:4340-4354. [ Abstract ]

52.  Li, J.P., Y.N. Fu, Y.R. Chen, and T.-H. Tan. 2010. JNK pathway-associated phosphatase dephosphorylates focal adhesion kinase and suppresses cell migration. J. Biol. Chem. 285:5472-5478. [ Abstract ]

53.  Chuang, H.C., J.L. Lan, D.Y. Chen, C.Y. Yang, Y.M. Chen, J.P. Li, C.Y. Huang, P.E. Liu, X. Wang, and T.-H. Tan. 2011. The kinase GLK controls autoimmunity and NF-kB signaling by activating the kinase PKC-θ in T cells . Nature Immunol. 12:1113-1118. [ Abstract ]

     Highlighted in News & Views of Nature Immunol. 12:1031-1032. [ link ]

     Highlighted in A-IMBN Research on 27 Dec. 27, 2011. [ link ]

54.  Wang, X., J.-P. Li, H.-K. Kuo, L.-L. Chiu, G.A. Dement, J.-L. Lan, D.-Y. Chen, C.-Y. Yang, H. Hu, and T.-H. Tan. 2012. Downregulation of B-cell receptor signaling by hematopoietic progenitor kinase 1 (HPK1)-mediated phosphorylation and ubiquitination of the activated BLNK. J. Biol. Chem. 287: 11037-11048. [ Abstract ]

55. Huang, C.-Y.*, Y.-C. Lin, W.-Y. Hsiao, F.-S. Liao, P.-Y. Huang, and T.-H. Tan*. 2012. DUSP4 deficiency enhances CD25 expression and CD4 T-cell proliferation without impeding T-cell development. Eur. J. Immunol. 42:476-488. [ Abstract ]

56. Wang X, Chuang HC, Li JP, T.-H. Tan. 2012. Regulation of PKC-θ function by phosphorylation in T cell receptor signaling. Front Immunol. 2012 Jul 11;3:197. doi: 10.3389/fimmu.2012.00197. Abstract ]

57. Huang, C.Y. and T.-H. Tan. 2012. DUSPs, to MAP kinases and beyond. Cell & Biosci. 2:24.  Abstract ]

58. Chen, D.Y., H.C. Chuang, J.L. Lan, Y.M. Chen, W.T. Hung, K.L. Lai and T.-H. Tan. 2012. Germinal center kinase-like kinase (GLK/MAP4K3) expression is increased in adult-onset Still's disease and may act as an activity marker. BMC Med.10:84. [ Abstract ]

59. Chen, K.R., C.H. Chang, C.Y.  Huang, C.Y. Lin, W.Y. Lin, Y.C. Lo, C.Y. Yang, E.W. Hsing, L.F. Chen, S.R. Shih, A.L. Shiau, H.Y. Lei, T.-H. Tan, and P. Ling. 2012. TBK1-associated Protein in Endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity. J. Biol. Chem. 287:32216-32221. [ Abstract ]

60. Wang, X.H., J.P. Li, L.L. Chiu, J.L. Lan, D.Y. Chen, J. Boomer, and T.-H. Tan. 2012. Attenuation of T cell receptor signaling by serine phosphorylation-mediated lysine 30 ubiquitination of SLP-76 protein. J. Biol. Chem. 287:34091-34100. [ Abstract ]

61. Chen, Y.-M., Chuang, H.-C., Lin, W.-C., Tsai, C.-Y., Wu, C.-W., Gong, N.-R., Hung, W.-T., Lan, T.-H., Lan, J.-L., Tan, T.-H., Chen, D.-Y. 2013. Germinal center kinase-like kinase overexpression in T cells as a novel biomarker in rheumatoid arthritis. Arthritis Rheum. 65:2573-2582.
[ Supplementary files ] [ Abstract ]

62. Su YW, Chen YP, Chen MY, Reth M, and  Tan, T.-H. 2013. The serine/threonine phosphatase PP4 is required for pro-B cell development through its promotion of Ig VDJ recombination. PLoS ONE.  8:e68804.  [ Abstract ]

63. Zhou G, Wang H, Liu SH, Shahi KM, Lin X, Wu J, Feng XH, Qin J, Tan, T.-H., Brunicardi FC. 2013. p38 MAP kinase interacts with and stabilizes pancreatic and duodenal homeobox-1. Curr. Mol. Med. 13:377-86. [ Abstract ]

64. Wang H, Chen Y, Lin P, Li L, Zhou G, Liu G, Logsdon C, Jin J, Abbruzzese JL, Tan, T.-H., Wang H. 2014. The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor Kinase 1. J. Biol.  Chem. 289:4009-4017. [ Abstract ]

65. Yang CY, Li JP, Chiu LL, Lan JL, Chen DY, Chuang HC, Huang CY, Tan, T.-H. 2014. Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation. J. Immunol.  192:1547-1557. [ Abstract ]

66. Li JP, Yang CY, Chuang HC, Lan JL, Chen DY, Chen YM, Wang X, Chen AJ, Belmont JW, Tan, T.-H. 2014. The phosphatase JKAP/DUSP22 inhibits T-cell receptor signalling and autoimmunity by inactivating Lck. Nature Communications. 5:3618. [ Abstract ]

67. Liao FH, Shui JW, Hsing EW, Hsiao WY, Lin YC, Chan YC, Tan, T.-H.* and Huang CY*. 2014. Protein phosphatase 4 is an essential positive regulator for Treg development, function, and protective gut immunity. Cell Biosci. 4:25. [ Abstract ]

68. Seeley-Fallen MK, Liu LJ, Shapiro MR, Onabajo OO, Palaniyandi S, Zhu X, Tan, T.-H, Upadhyaya A, Song W. 2014. Actin-binding protein 1 links B-cell antigen receptors to negative signaling pathways. Proc Natl Acad Sci U S A. 111:9881-6. [ Abstract ]

69. Chuang HC, Sheu WH, Lin YT, Tsai CY, Yang CY, Cheng YJ, Huang PY, Li JP, Chiu LL, Wang X, Xie M, Schneider MD, Tan, T.-H. 2014. HGK/​MAP4K4 deficiency induces ​TRAF2 stabilization and Th17 differentiation leading to insulin resistance. Nature Communications. 5:4602. [ Abstract ]

70. MY Chen, YP Chen, MS Wu, GY Yu, WJ Lin, Tan, Tan, T.-H. and Yu-Wen Su*. 2014. PP4 is essential for germinal center formation and class switch recombination in mice. PLoS One. 12:e107505. [ Abstract ]

71. Chuang HC, Wang X, Tan T.-H. 2016. MAP4K family kinases in immunity and inflammation.Advances in Immunology. 129:277. [ Abstract ]

72. CY Yang, LL Chiu, Tan, T.-H. 2016. TRAF2-mediated Lys63-linked ubiquitination of DUSP14/MKP6 is essential for its phosphatase activity. Cellular Signalling. 28:145.[ Abstract ]

 73. HC Chuang, JS Wang, IT Lee, W H-H. Sheu* and Tan, T.-H*. 2016. Epigenetic regulation of HGK/MAP4K4 in T cells of type 2 diabetes patients. Oncotarget. 7:10976-10989.[ Abstract ]

74. Hsu CP, Chuang HC, Lee MC, Tsou HH, Lee LW, Li JP, Tan, T.-H*. 2016. GLK/MAP4K3 overexpression associates with recurrence risk for non-small cell lung cancer. Oncotarget. 7:41748-41757.[ Abstract ]

75. Ho CH, Chuang HC, Wu IC, Tsai HW, Lin YJ, Sun HY, Young KC, Chiu YC, Cheng PN, Liu WC, Tan, T.-H* and Chang TT* 2016. Prediction of early hepatocellular carcinoma recurrence using germinal center kinase-like kinase. Oncotarget. 7:49765-49776.[ Abstract ]

76. Chuang, H.C, Y. M Chen, W.T. Hung, J.P. Li, D.Y. Chen*, J.L. Lan* and Tan, T.-H*. 2016. Downregulation of the phosphatase JKAP/DUSP22 in T Cells as a potential new biomarker of systemic lupus erythematosus nephritis. Oncotarget. 7:57593-57605.[ Abstract ]

77. Ruan JW, Statt S, Huang CT, Tsai YT, Kuo CC, Chan HL, Liao YC, Tan TH, Kao CY*. 2016. Dual-specificity phosphatase 6 deficiency regulates gut microbiome and transcriptome response against diet-induced obesity in mice. Nature Microbiology. 2:16220.[ Abstract ]

78. Chuang, HC and T.-H. Tan*. 2017. MAP4K4 and IL-6+ Th17 cells play important roles in non-obese type 2 diabetes. Journal of Biomedical Science. (Invited review) 24:4.[ Abstract ]

79. Chuang, HC and T.-H. Tan*. 2017. MAP4K3 (GLK). Encyclopedia of Signaling Molecules. (Book-chapter) Pages: 1-5.[ Abstract ]

80. YR Chen, HC Chou, CH Yang, HY Chen, YW Liu, TY Lin, CL Yeh, WT Chao, HH Tsou, HC Chuang and T.-H. Tan*. 2017. Deficiency in VHR/DUSP3, a suppressor of focal adhesion kinase, reveals its role in regulating cell adhesion and migration. Oncogene. Online publication 31 July 2017. [ Abstract ]



Patents

專利名稱 發明人 日期 國家 編號
MAP kinase kinase kinase kinase 3 (MAP4K3) as a biomarker and therapeutic target for autoimmune disease, cancer, inflammation and IL-17-associated disease Chuang HC and Tan TH. 2017 China 領證中
MAP kinase kinase kinase kinase 3 (MAP4K3) as a biomarker and therapeutic target for autoimmune disease, cancer, inflammation and IL-17-associated disease Chuang HC and Tan TH. 2015 台灣 專利證號發明第I-510629號
MAP kinase kinase kinase kinase 3 (MAP4K3) as a biomarker and therapeutic target for autoimmune disease, cancer, inflammation and IL-17-associated disease Chuang HC and Tan TH. 2017 Europe 領證中
Phosphatases which activate MAP kinase pathways Jonn W. Belmont, Frederick A. Fletcher, Alice J. Chen, Roland Jurecic, Tse-Hua Tan, Guisheng Zhou, and Amgen, Inc. 2007 USA U.S. Patent No. 7,195,902 B2
MAP kinase kinase kinase kinase 3 (MAP4K3) as a biomarker and therapeutic target for autoimmune disease, cancer, inflammation and IL-17-associated disease Chuang HC and Tan TH. 2016 South Korea Korea. Patent No.10-1640326
MAP kinase kinase kinase kinase 3 (MAP4K3) as a biomarker and therapeutic target for autoimmune disease, cancer, inflammation and IL-17-associated disease Chuang HC and Tan TH. 2014 USA U.S. Patent No. Patent No. 8,846,311 B2

更新日期:2017-10-27

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