蔡世峰 研究員

聯絡電話：(037) 246-166 ext. 35310
傳　　真：(037) 586-459
電子信箱：petsai@nhri.org.tw

專長 | 學歷 | 經歷 | 研究興趣 | 研究著作

專 長
1. Genomic Medicine
2. Human Genetics

學 歷
台北醫學院 醫學士
美國紐約市立大學西奈山醫學院 哲學博士

經 歷  
1987-1988

美國紐約市立大學西奈山醫學院 人類遺傳學系 研究員
1988-1990

美國波士頓兒童醫院 血液腫瘤科 研究員

1988-1990
美國哈佛醫學院 小兒科 研究員
1991-1997

國立陽明大學 遺傳所 副教授

1997- 迄今

國立陽明大學 遺傳所 教授

2000-2008

國家衛生研究院 分子與基因醫學研究組 組主任

2008- 迄今
 國家衛生研究院 分子與基因醫學研究組 研究員

研 究 興 趣
過去數年來，我們對正常肝臟與肝癌組織之基因表現深感興趣，本實驗室應用先進科技，大量分析基因之表現。研究結果顯示蛋白激脢在不同生理病理狀況下有不同的表現型式。我們也透過團隊合作，建立研究肝臟相關研究所需之基因庫材料並且分析了數千筆肝臟之基因序列。這些資訊可供研究者參考，從中找尋研究的新方向。最近，我們更致力建立百萬鹼基級之基因定序能力，除了協助搜尋可能之抑癌基因外，亦可對人類基因組計劃有所貢獻。

人類基因體計畫 (The Human Genome Project)，自1998年進入一個高峰。藉由先前遺傳圖譜 (genetic map)及物理圖譜 (physical map) 之基礎，全球之基因體研究重點轉向人類基因體之定序工作。目前已經發表有完整之第二十一、二十二號兩個染色體之完成序列 (finished sequence)，以及其它染色體之初稿序列 (draft sequence)，這些基因體資訊提供未來生物醫學研究之重要基礎。本人實驗室自1998年開始規劃台灣之大規模基因體定序能力，建立年產千萬鹼基 (10 Mb)之核心設施，截至目前已對公眾資料庫提供1200萬以上高精確度之序列，主要集中於人類第四號染色體4q21-24 區域，此區域在肝癌病患肝臟細胞基因體經常出現缺失。這些成果可參考網頁資料(網址 http://genome.ym.edu.tw)。

在4q21-24 區域中，除了可能之抑癌基因 (tumor suppressor gene) 外，尚有上百個基因，其中有些與人類之疾病有關。例如 PKD2基因與體染色體顯性之成年型多囊腎疾病(polycystic kidney disease)有關，SNCA 基因與巴金森氏症(Parkinson disease)有關。這些基因具有重要之醫學意義，值得進一步探討。由於基因表現調控受到染色體局部及整體環境之影響，人類基因體序列除了可以協助發現基因(gene discovery)外，亦對研究基因表現之調控機制提供新的線索。本實驗室完成人類ADH 基因與小鼠Adh基因之比較分析，找出控制整個第一型ADH基因座(Class I ADH gene complex)之關鍵區域。目前正以轉殖鼠技術與生化學方法進一步研究基因調控之機制。

基因體科技之進展逐漸與臨床醫學結合，對於疾病之診斷、分類、治療與預防作出貢獻。本人實驗室已建立基因體分析技術，例如微陣列及突變分析之標準程序，將可找出與疾病相關之基因，並進一步剖析基因變異造成人類疾病之病理過程。這些資訊的取得雖然費時耗力，但將可加速對人類疾病之掌握，甚至帶動對於病人治療方式之新的突破。

由於基因的運作原理是演化保留下的生物基本法則，本實驗室運用此一觀念找尋人類與果蠅共通之基因並研究其功能。目前已發現數個基因與調節染色質結構及基因表現有關，目前正進一步探討其生理功能。

研 究 著 作
1. Tsai SF, Bishop DF, & Desnick RJ. (1987) Purification and properties of uroporphyrinogen III synthase from human erythrocytes. J. Biol. Chem. 262, 1268-1273.
2. Tsai SF, Bishop DF, & Desnick RJ. (1987) Coupled-enzyme and direct assays for uroporphyrinogen III synthase activity in human erythrocytes and cultured lymphoblasts. Enzymatic diagnosis of heterozygotes and homozygotes with congenital erythropoietic porphyria. Anal. Biochem. 166, 120-133.
3. Tsai SF, Bishop DF, & Desnick RJ. (1988) Human uroporphyrinogen III synthase: molecular cloning, nucleotide sequence, and expression of a full-length cDNA. Proc. Natl. Acad. Sci. USA. 85, 7049-7053.
4. Martin DIK, Tsai SF, & Orkin SH. (1989) Increased g-globin expression in a nondeletion HPFH mediated by an erythroid-specific DNA binding factor. Nature (London) 338, 435-438.
5. Tsai SF, Martin DIK, Zon LI., D'Andrea AD, Wong G.G. & Orkin SH. (1989) Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells. Nature (London) 339, 446-451.
6. Zon LI, Tsai SF, Burgess S, Matsudaira P, Bruns G.A, & Orkin SH.(1990) The major human erythroid DNA-binding protein (GF-1): Primary sequence and localization of the gene to the X chromosome. Proc. Natl. Acad. Sci. USA. 87, 668-672.
7. Whitelaw E, Tsai SF, Hogben P, & Orkin SH. (1990) Regulated expression of globin chains and the erythroid transcription factor (GF-1/NF-E1/Eryf1) during erythropoiesis in the developing mouse. Mol. Cell. Biol. 10: 6596-6606.
8. Pevny L, Simon MC, Robertson E, Klein WH, Tsai SF, D'Agati V, Orkin SH, & Costantini F. (1991) A targeted mutation in the gene for transcription factor GATA-1 blocks erythroid differentiation in chimeric mice. Nature (London) 349: 257-260.
9. Tsai SF, Strauss E, & Orkin SH. (1991) Functional analysis and in vivo footprinting implicate the erythroid transcription factor GATA-1 as a positive regulator of its own promoter. Genes & Dev. 5: 919-931.
10. Ho IC, Vorhees P, Marin N, Karpinski Oakley B, Tsai SF, Orkin SH, & Leiden J M. (1991) Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor a gene. EMBO J. 10: 1187-1192.
11. Astrin KH, Warner CA, Yoo HK, Goodfellow PJ, Tsai SF, & Desnick RJ. (1991) Regional assignment of the human uroporphyrinogen III synthase (UROS) gene to chromosome 10q25.2 -q26.3. Hum. Genet. 87: 18-22.
12. Warner CA, Poh-Fitzpatrick MB, Zaider EF, Tsai SF, & Desnick RJ. (1992) Congenital erythropoietic porphyria, A mild variant with low uroporphyrin I level due to a missense mutation (A66V) encoding residual uroporphyrinogen III synthase activity. Arch. Dermatol. 128: 1243-1248.
13. Pai JT, Tsai SF, Horng CJ, Chiu PC, Cheng MY, Hsiao KJ, & Wu KD. (1994) Absence of FMR-1 gene expression can be detected with RNA extracted from dried blood specimens. Hum. Genet. 93: 488-493.
14. Skoda RC, Tsai SF, Orkin SH, & Leder P. (1995) Expression of c-MYC under the control of GATA-1 Regulatory sequences causes erythroleukemia in transgenic mice. J. Exp. Med. 181: 1603-1613.
15. Lin WH, Huang LH., Yeh JY, Hoheisel J, Lehrach H, Sun YH, & Tsai SF. (1995) Expression of a Drosophila GATA transcription factor in multiple tissues in the developing embryos. Identification of homozygous lethal mutants with P-element insertion at the promoter region. J. Biol. Chem. 27: 25150-25158.
16. Lee DD, Huang JY, Wong CK., Gagel RF, & Tsai SF. (1996) Genetic heterogeneity of familial primary cutaneous amyloidosis: Lack of evidence for linkage with the chromosome 10 pericentromeric region in Chinese families. J. Inv. Derma. 107: 30-33.
17. Tsai SF, Jang A CC, Prikhod'Ko G., Bessarab DA, Tang CY, Pflugfelder GO, & Sun YH. (1997) Gypsy retrotransposon as a tool for the in vivo analysis of the regulatory region of the optomotor-blind gene in Drosophila . Proc. Natl. Acad. Sci. USA. 94: 3837-3841.
18. Fan FF, Shen HH, Tseng WP, Chen PM, & Tsai SF. Molecular cloning and characterization of a human brain-specific gene implicated in neuronal differentiation. (1998) Molecular Brain Research 54: 113-123.
19. Tsou AP, Wu KM, Tseng TI, Chi CW, Chiu JW, Lui WY, Hu CP, Chang C, Chou,CK, & Tsai SF. Parallel hybridization analysis of multiple protein kinase genes: identification of gene expression patterns characteristic of human hepatocellular carcinoma. (1998) Genomics 50: 331-340.
20. Chen YJ, Chen PJ, Shu CH, Hsu MT, Tsai SF, & Lin CH. Chromosomal aberrations in nasopharyngeal carcinoma analyzed by comparative genomic hybridization. (1999) Genes Chromosomes and Cancer 25:169-175.
21. Chen YJ, Yeh SH., Chen JT, Wu CC, Hsu MT, Tsai SF, Chen PJ, & Lin CH. Chromosomal changes and clonality relationship between primary and recurrent hepatocellular carcinoma. (2000) Gastroenterology 119(2):431-440.
22. Tsai SF, & Chen PJ. The impact of human genome research on medicine -- The initial Taiwan Experience. (2000) Journal of the Formosan Medical Association 99(2):107-115.
23. Bressler J, Tsai TF, Wu MY, Tsai, SF, Ramirez MA, Armstrong D, & Beaudet AL. The SNRPN prrmoter is not required for genomic imprinting of the Prader-Willi/Angelman domain in mice. (2001) Nat. Genet. 28:232-240.
24. Shen HH, Huang AM, Hoheisel J, & Tsai SF. Identification and characterization of a SET/NAP protein encoded by the brain-specific gene, MB20. (2001) Genomics 71(1): 21-33.
25. Chang YT, Tsai SF, Wang WJ, Hong CJ, Huang CY, & Wong CK. A study of apolipoproteins E and A-l in cutaneous amyloids. (2001) Br. J. Dermatol. 145:422-427.
26. Fujiyama A, Watanabe H, Toyoda A, Taylor TD, Itoh T, Tsai SF, Park HS, Yaspo ML, Lehrach H, Chen Z, Fu G, Saitou N, Osoegawa K, de Jong PJ, Suto Y, Hattori M, & Sakaki Y. (2002) Construction and analysis of the first human-chimpanzee comparative clone map. Science 295:131-134.
27. Chang YT, Tsai SF, Lee DD, Shiao YM, Huang CY, Liu HN, Wang WJ & Wong CK. A study of candidate genes for psoriasis near HLA-C in Chinese patients with psoriasis. (2003) British Journal of Dermatology. 148(3):418-423.
28. Chang YT, Tsai SF, Lin MW, Liu HN, Lee DD, Shiao YM, Chin PJ, & Wang WJ. SPR1 gene near HLA-C is unlikely to be a psoriasis susceptibility gene. (2003) Experimental Dermatology. 12:307-314. 
29. Chen CY*, Wu KM*, Chang YC, Chang C-H, Tsai HC, Liao TL, Liu YM, Chen HJ, Shen Arthur BT, Li JC, Su TL, Shao CP, Lee CT, Hor LI, & Tsai SF.Comparative genome analysis of Vibrio vulnificus, a marine pathogen. (2003) Genome Research 13: 2577-2587.
30. Liu MT*, Su JS*, Huang CY & Tsai SF. Novel Mutations Involving the NF1 Gene Coding Sequence in Neurofibromatosis Type 1 Patients from Taiwan. (2003) J Hum Genet. 48(10):545-549.
31. Sakaki Y, Watanabe H, Taylor T, Hattori M, Fujiyama A, Toyoda A, Kuroki Y, Itoh T, Saitou N, Oota S, Kim CG, Kitano T, Lehrach H, Yaspo ML, Sudbrak R, Kahla A, Reinhardt R, Kube M, Platzer M, Taenzer S, Galgoczy P, Kel A, Bloecker H, Scharfe M, Nordsiek G, Hellmann I, Khaitovich P, Paabo S, Chen Z, Wang SY, Ren SX, Zhang XL, Zheng HJ, Zhu GF, Wang BF, Zhao GP, Tsai SF, Wu K, Liu TT, Hsiao KJ, Park HS, Lee YS, Cheong JE, Choi SH; Chimpanzee Chromosome 22 Sequencing Consortium. Human versus chimpanzee chromosome-wide sequence comparison and its evolutionary implication. (2003) Cold Spring Harb Symp Quant Biol. 68:455-460.
32. Jong YJ, Li LH, Tsou MH, Chen YJ, Cheng SH, Wang-Wuu S, Tsai SF, Chen CM, Huang AT, Hsu MT & Lin CH. Chromosomal comparative genomic hybridization abnormalities in early- and late-onset human breast cancers: correlation with disease progression and TP53 mutations. (2004) Cancer Genet Cytogenet. 148(1):55-65.
33. Huang CJ, Chen CY, Chen HH, Tsai SF & Choo KB. TDPOZ, a family of bipartite animal and plant proteins that contain the TRAF(TD) and POZ/BTB domains. (2004) Gene 324:117-127.
34. Li LH, Li JC, Lin YF, Lin CY, Chen CY & Tsai SF. Genomic shotgun array: a procedure linking large-scale DNA sequencing with regional transcript mapping. (2004) Nucleic Acids Res.32(3):E27. 
35. Yeh SH, Wang HY, Tsai CY, Kao CL, Yang JY, Liu HW, Su IJ, Tsai SF, Chen DS, Chen PJ, The National Taiwan University SARS Research Team, Chen DS, Lee YT, Teng CM, Yang PC, Ho HN, Chen PJ, Chang MF, Wang JT, Chang SC, Kao CL, Wang WK, Hsiao CH, Hsueh PR. Characterization of severe acute respiratory syndrome coronavirus genomes in Taiwan: Molecular epidemiology and genome evolution. (2004) Proc. Natl. Acad. Sci. USA. 101(8):2542-2547.
36. The International Chimpanzee Chromosome 22 Consortium: Watanabe H, Fujiyama A, Hattori M, Taylor TD, Toyoda A, Kuroki Y, Noguchi H, BenKahla A, Lehrach H, Kube M, Sudbrak R, Taenzer S, Galgoczy P, Platzer M, Scharfe M, Nordsiek G, Blocker H, Hellmann I, Khaitovich P, Paabo S, Reinhardt R, Zheng HJ, Zhang XL, Zhu GF, Wang BF, Fu G, Ren SX, Zhao GP, Chen Z, Lee YS, Cheong JE, Choi SH, Wu KM, Liu TT, Hsiao KJ, Tsai SF, Kim CG, Oota S, Kitano T, Kohara Y, Saitou N, Park HS, Wang SY, Yaspo ML, Sakaki Y. DNA sequence and comparative analysis of chimpanzee chromosome 22. (2004) Nature 429: 382-388.
37. Chang YT, Shiao YM, Chin PJ, Liu YL, Chou FC, Wu S, Lin YF, Li LH, Lin MW, Liu HN, Tsai SF. Genetic polymorphisms of the HCR gene and a genomic segment in close proximity to HLA-C are associated with patients with psoriasis in Taiwan. (2004) Br. J. Dermatol. 150(6):1104-1111.
38. Bartholomay LC, Cho WL, Rocheleau TA, Boyle JP, Beck ET, Fuchs JF, Liss P, Rusch M, Butler KM, Wu RC, Lin SP, Kuo HY, Tsao IY, Huang CY, Liu TT, Hsiao KJ, Tsai SF, Yang UC, Nappi AJ, Perna NT, Chen CC, Christensen BM. Description of the Transcriptomes of Immune Response-Activated Hemocytes from the Mosquito Vectors Aedes aegypti and Armigeres subalbatus. (2004) Infect. Immun. 72(7):4114-4126.
39. Chen WM, Liu YF, Lin MW, Chen IC, Lin PY, Lin GL, Jou YS, Lin YT, Fann CS, Wu JY, Hsiao KJ & Tsai SF. Autosomal dominant avascular necrosis of femoral head in two Taiwanese pedigrees and linkage to chromosome 12q13. (2004) Am. J. Hum. Genet. 75(2): 310-317.
40. Chang YT, Liu HN, Wang WJ, Lee DD, Tsai SF. A study of cytokeratin profiles in localized cutaneous amyloids. (2004) Arch. Dermatol. Res. 296(2): 83-88.
41. Chen YT, Chang HY, Lai YC, Pan CC, Tsai SF, Peng HL. Sequencing and analysis of the large virulence plasmid pLVPK of Klebsiella pneumoniae CG43. (2004) Gene 337:189-198.
42. Kao WC, Chen YR, Yi EC, Lee H, Tian Q, Wu KM, Tsai SF, Yu SS, Chen YJ, Aebersold R, Chan SI. Quantitative proteomic analysis of metabolic regulation by copper ions in methylococcus capsulatus (Bath). (2004) J Biol Chem. 279(49):51554-51560.
43. Yeh SH, Lin MW, Lu SF, Wu DC, Tsai SF, Tsai CY, Lai MY, Hsu HC, Chen DS, Chen PJ. Allelic loss of chromosome 4q21 approximately 23 associates with hepatitis B virus-related hepatocarcinogenesis and elevated alpha-fetoprotein. (2004) Hepatology. 40(4):847-854.
44. Huang SF, Liu HP, Li LH, Ku YC, Fu YN, Tsai HY, Chen YT, Lin YF, Chang WC, Kuo HP, Wu YC, Chen YR, Tsai SF. High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to gefitinib responsiveness in Taiwan. (2004) Clin Cancer Res. 10(24):8195-8203.
45. Tsai HY, Hsi BL, Hung IJ, Yang CP, Lin JN, Chen JC, Tsai SF, Huang SF. Correlation of MYCN amplification with MCM7 protein expression in neuroblastomas: a chromogenic in situ hybridization study in paraffin sections. (2004) Hum Pathol. 35(11):1397-1403.
46. Chang YH, Su WH, Lee TC, Sun HF, Chen CH, Pan WH, Tsai SF, Jou YS. TPMD: a database and resources of microsatellite marker genotyped in Taiwanese populations. (2005) Nucleic Acids Res. Database Issue:D174-177.
47. Lin MW, Lee DD, Lin CH, Huang CY, Wong CK, Chang YT, Liu HN, Hsiao KJ, Tsai SF. Suggestive Linkage of Familial Primary Cutaneous Amyloidosis to a Locus on Chromosome 1q23. (2005) Br J Dermatol. 152(1):29-36.
48. Liu YF, Chen WM, Lin YF, Yang RC, Lin MW, Li LH, Chang YH, Jou YS, Lin PY, Su JS, Huang SF, Hsiao KJ, Fann CS, Hwang HW, Chen YT, Tsai SF. Type II collagen gene variants and inherited osteonecrosis of the femoral head. (2005) N Engl J Med. 352(22):2294-2301.
49. Chou TY, Chiu CH, Li LH, Hsiao CY, Tzen CY, Chang KT, Chen YM, Perng RP, Tsai SF, Tsai CM. Mutation in the tyrosine kinase domain of epidermal growth factor receptor is a predictive and prognostic factor for gefitinib treatment in patients with non-small cell lung cancer. (2005) Clin Cancer Res. 11(10):3750-3757.
50. Chang YT, Liu HN, Yu CW, Lin MW, Huang CH, Chen CC, Liu MT, Lee DD, Wang WJ, Tsai SF. Cytokine gene polymorphisms in bullous pemphigoid in a Chinese population. (2006) Br J Dermatol.154(1):79-84.
51. Chen YR, Fu YN, Lin CH, Yang ST, Hu SF, Chen YT, Tsai SF, Huang SF. Distinctive activation patterns in constitutively active and gefitinib-sensitive EGFR mutants. (2006) Oncogene. 25(8):1205-1215.
52. Chang YT, Lee WR, Yu CW, Liu HN, Lin MW, Huang CH, Chen CC, Lee DD, Wang WJ, Hu CH, Tsai SF. No association of cytokine gene polymorphisms in Chinese patients with atopic dermatitis. (2006) Clin Exp Dermatol. 31:419-423.
53. Su JS, Tsai TF, Chang HM, Chao KM, Su TS, Tsai SF. Distant HNF1 site as a master control for the human class I alcohol dehydrogenase gene expression. (2006) J Biol Chem. 281:19809-19821.
54. Hsieh MH, Fang YF, Chang WC, Kuo HP, Lin SY, Liu HP, Liu CL, Chen HC, Ku YC, Chen YT, Chang YH, Chen YT, Hsi BL, Tsai SF, Huang SF. Complex Mutation Patterns of Epidermal Growth Factor Receptor Gene Associated with Variable Responses to Gefitinib Treatment in Patients with Non-Small Cell Lung Cancer. (2006) Lung Cancer 53(3):311-322.
55. Chang YT, Chou CT, Shiao YM, Lin MW, Yu CW, Chen CC, Huang CH, Lee DD, Liu HN, Wang WJ, Tsai SF. The killer cell immunoglobulin-like receptor genes do not confer susceptibility to psoriasis vulgaris independently in Chinese. (2006) J Invest Dermatol. 126(10):2335-2338.
56. Chang YT, Chou CT, Shiao YM, Lin MW, Yu CW, Chen CC, Huang CH, Lee DD, Liu HN, Wang WJ, Tsai SF. Psoriasis vulgaris in Chinese is associated with PSORS1C3 and CDSN genes. (2006) Br J Dermatol. 155(4):663-669.
57. Lee DD, Lin MW, Chen IC, Huang CY, Liu MT, Wang CR, Chang YT, Liu HN, Liu TT, Wong CK, Tsai SF. Genome-Wide Scan Identifies a Susceptibility Locus for Familial Primary Cutaneous Amyloidosis on Chromosome 5p13.1-q11.2. (2006) Br J Dermatol. 155(6):1201-8.
58. Chen YT, Shu HY, Li LH, Liao TL, Wu KM, Shiau YR, Yan JJ, Su IJ, Tsai SF, Lauderdale TL. Complete Nucleotide Sequence of pK245, a 98-Kilobase Plasmid Conferring Quinolone Resistance and Extended-Spectrum-{beta}-Lactamase Activity in a Clinical Klebsiella pneumoniae Isolate. (2006) Antimicrob Agents Chemother. 50(11):3861-3866.
59. Hung KW, Lin YC, Cheng CC, Fan PJ, Chang CF, Tsai SF, Huang TH. Resonance assignments of a CoA binding protein from Klebsiella pneumoniae. (2006) J Biomol NMR. 36(5):74.
60. Wang HY, Chien HC, Osada N, Hashimoto K, Sugano S, Gojobori T, Chou CK, Tsai SF, Wu CI, Shen CK. Rate of Evolution in Brain-Expressed Genes in Humans and Other Primates. (2007) PLoS Biol. 5(2):e13.
61. Chang YT, Hsu CY, Chou CT, Lin MW, Shiao YM, Tsai CY, Yu CW, Shiue JJ, Lee YF, Huang CH, Chen CC, Lee DD, Wang WJ, Liu HN, Tsai SF. The genetic polymorphisms of POU5F1 gene are associated with psoriasis vulgaris in Chinese. (2007) J Dermatol Sci. 46(2):153-156.
62. Chang YT, Chou CT, Yu CW, Lin MW, Shiao YM, Chen CC, Huang CH, Lee DD, Liu HN, Wang WJ, Tsai SF. Cytokine gene polymorphisms in Chinese patients with psoriasis. (2007) Br J Dermatol. 156(5):899-905.
63. Chung WJ, Shu HY, Lu CY, Wu CY, Tseng YH, Tsai SF, Lin CH. Qualitative and comparative proteomic analysis of Xanthomonas campestris pv. campestris 17. (2007) Proteomics 7(12):2047-2058.
64. Chen YT, Lauderdale T, Liao TL, Shiau YR, Shu HY, Wu KM, Yan JJ, Su IJ, Tsai SF. Sequencing and Comparative Genomic Analysis of pK29, a 269-kb Conjugative Plasmid Encoding CMY-8 and CTX-M-3 beta-lactamases from Klebsiella pneumoniae. (2007) Antimicrob Agents Chemother. 51(8):3004-3007.
65. Fu YN, Yeh CL, Cheng HY, Yang CH, Tsai SF, Huang SF, Chen YR. EGFR mutants found in non-small cell lung cancer show different levels of sensitivity to suppression of Src: implications in targeting therapy. (2008) Oncogene 27(7):957-965.
66. Mayhew GF, Bartholomay LC, Kou HY, Rocheleau TA, Fuchs JF, Aliota MT, Tsao IY, Huang CY, Liu TT, Hsiao KJ, Tsai SF, Yang UC, Perna NT, Cho WL, Christensen BM, Chen CC.Construction and characterization of an expressed sequenced tag library for the mosquito vector Armigeres subalbatus. (2007) BMC Genomics. 8:462.
67. Wu JH, Wu AM, Tsai CG, Chang XY, Tsai SF, Wu TS.Contribution of fucose-containing capsules in Klebsiella pneumoniae to bacterial virulence in mice. (2008) Exp Biol Med (Maywood) 233(1):64-70.
68. Lin TL, Lee CZ, Hsieh PF, Tsai SF, Wang JT.Characterization of integrative and conjugative element ICEKp1-associated genomic heterogeneity in a Klebsiella pneumoniae strain isolated from a primary liver abscess. (2008) J Bacteriol. 190(2):515-626.
69. Lee CT, Amaro C, Wu KM, Valiente E, Chang YF, Tsai SF, Chang CH, Hor LI. A common virulence plasmid in biotype 2 Vibrio vulnificus and its dissemination aided by a conjugal plasmid. (2008) J Bacteriol. 190(5):1638-1648.
70. Furuichi T, Maeda K, Chou CT, Liu YF, Liu TC, Miyamoto Y, Takahashi A, Mori K, Ikari K, Kamatani N, Kurosawa H, Inoue H, Tsai SF, Ikegawa S. Association of the MSX2 gene polymorphisms with ankylosing spondylitis in Japanese. (2008) J Hum Genet 53(5):419-424.
71. Dou HY, Tseng FC, Lu JJ, Jou R, Tsai SF, Chang JR, Lin CW, Miu WC, Su IJ. Associations of Mycobacterium tuberculosis genotypes with different ethnic and migratory populations in Taiwan. (2008) Infect Genet Evol. 8(3):323-30.
72. Lin WH, Song JS, Chang TY, Chang CY, Fu YN, Yeh CL, Wu SH, Huang YW, Fang MY, Lien TW, Hsieh HP, Chao YS, Huang SF, Tsai SF, Wang LM, Hsu JT, Chen YR. A cell-based high-throughput screen for epidermal growth factor receptor pathway inhibitors. (2008) Anal Biochem. 377(1):89-94.
73. Chang JW, Liu HP, Hsieh MH, Fang YF, Hsieh MS, Hsieh JJ, Chiu YT, Tsai HY, Chen YH, Chen YT, Hsu HY, Chen YT, Tsai SF, Chen YR, Hsi BL, Huang SF. Increased epidermal growth factor receptor (EGFR) gene copy number is strongly associated with EGFR mutations and adenocarcinoma in non-small cell lung cancers: A chromogenic in situ hybridization study of 182 patients. Lung Cancer. 2008 Feb 25; [Epub ahead of print]
74. Hsieh PF, Lin TL, Lee CZ, Tsai SF, Wang JT. Serum-Induced Iron-Acquisition Systems and TonB Contribute to Virulence in Klebsiella pneumoniae Causing Primary Pyogenic Liver Abscess. J Infect Dis. 2008 Apr 23. [Epub ahead of print]
75. Shiao YM, Chang YH, Liu YM, Li JC, Su JS, Liu KJ, Liu YF, Lin MW, Tsai SF. Dysregulation of GIMAP genes in non-small cell lung cancer. Lung Cancer. 2008 May 5. [Epub ahead of print]

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